Interleukin-4 receptor

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

PBB_Summary
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summary_text = This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [cite web | title = Entrez Gene: IL4R interleukin 4 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nelms K, Keegan AD, Zamorano J, "et al." |title=The IL-4 receptor: signaling mechanisms and biologic functions. |journal=Annu. Rev. Immunol. |volume=17 |issue= |pages= 701–38 |year= 1999 |pmid= 10358772 |doi= 10.1146/annurev.immunol.17.1.701
*cite journal | author=Jiang H, Harris MB, Rothman P |title=IL-4/IL-13 signaling beyond JAK/STAT. |journal=J. Allergy Clin. Immunol. |volume=105 |issue= 6 Pt 1 |pages= 1063–70 |year= 2000 |pmid= 10856136 |doi=

External links

*

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