IL1RAP

Interleukin 1 receptor accessory protein, also known as IL1RAP, is a human gene.cite web | title = Entrez Gene: IL1RAP interleukin 1 receptor accessory protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3556| accessdate = ]

PBB_Summary
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summary_text = Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.cite web | title = Entrez Gene: IL1RAP interleukin 1 receptor accessory protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3556| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Greenfeder SA, Nunes P, Kwee L, "et al." |title=Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13757–65 |year= 1995 |pmid= 7775431 |doi=
*cite journal | author=Parnet P, Garka KE, Bonnert TP, "et al." |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967–70 |year= 1996 |pmid= 8626725 |doi=
*cite journal | author=Wesche H, Korherr C, Kracht M, "et al." |title=The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). |journal=J. Biol. Chem. |volume=272 |issue= 12 |pages= 7727–31 |year= 1997 |pmid= 9065432 |doi=
*cite journal | author=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=
*cite journal | author=Dale M, Hammond DW, Cox A, Nicklin MJ |title=The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=47 |issue= 2 |pages= 325–6 |year= 1998 |pmid= 9479509 |doi= 10.1006/geno.1997.5113
*cite journal | author=Cullinan EB, Kwee L, Nunes P, "et al." |title=IL-1 receptor accessory protein is an essential component of the IL-1 receptor. |journal=J. Immunol. |volume=161 |issue= 10 |pages= 5614–20 |year= 1998 |pmid= 9820540 |doi=
*cite journal | author=Lang D, Knop J, Wesche H, "et al." |title=The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness. |journal=J. Immunol. |volume=161 |issue= 12 |pages= 6871–7 |year= 1999 |pmid= 9862719 |doi=
*cite journal | author=Morton NM, de Groot RP, Cawthorne MA, Emilsson V |title=Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells. |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 57–60 |year= 1999 |pmid= 9923604 |doi=
*cite journal | author=Sizemore N, Leung S, Stark GR |title=Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4798–805 |year= 1999 |pmid= 10373529 |doi=
*cite journal | author=Jensen LE, Muzio M, Mantovani A, Whitehead AS |title=IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein. |journal=J. Immunol. |volume=164 |issue= 10 |pages= 5277–86 |year= 2000 |pmid= 10799889 |doi=
*cite journal | author=Burns K, Clatworthy J, Martin L, "et al." |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346–51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038
*cite journal | author=Bigonnesse F, Marois M, Maheux R, Akoum A |title=Interleukin-1 receptor accessory protein is constitutively expressed in human endometrium throughout the menstrual cycle. |journal=Mol. Hum. Reprod. |volume=7 |issue= 4 |pages= 333–9 |year= 2001 |pmid= 11279295 |doi=
*cite journal | author=Jefferies C, Bowie A, Brady G, "et al." |title=Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1. |journal=Mol. Cell. Biol. |volume=21 |issue= 14 |pages= 4544–52 |year= 2001 |pmid= 11416133 |doi= 10.1128/MCB.21.14.4544-4552.2001
*cite journal | author=Radons J, Gabler S, Wesche H, "et al." |title=Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16456–63 |year= 2002 |pmid= 11880380 |doi= 10.1074/jbc.M201000200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ruhul Amin AR, Machida K, Oshima K, "et al." |title=A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. |journal=Oncogene |volume=21 |issue= 57 |pages= 8871–8 |year= 2003 |pmid= 12483539 |doi= 10.1038/sj.onc.1206018
*cite journal | author=Smith DE, Hanna R, Della Friend, "et al." |title=The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. |journal=Immunity |volume=18 |issue= 1 |pages= 87–96 |year= 2003 |pmid= 12530978 |doi=
*cite journal | author=Boch JA, Yoshida Y, Koyama Y, "et al." |title=Characterization of a cascade of protein interactions initiated at the IL-1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=303 |issue= 2 |pages= 525–31 |year= 2003 |pmid= 12659850 |doi=
*cite journal | author=Bin LH, Xu LG, Shu HB |title=TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24526–32 |year= 2003 |pmid= 12721283 |doi= 10.1074/jbc.M303451200
*cite journal | author=Jensen LE, Whitehead AS |title=Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis. |journal=Cell. Signal. |volume=15 |issue= 8 |pages= 793–802 |year= 2004 |pmid= 12781872 |doi=

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