Interleukin 12 receptor, beta 2 subunit

Interleukin 12 receptor, beta 2 subunit

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.cite web | title = Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3595| accessdate = ]

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summary_text = The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.cite web | title = Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3595| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Airoldi I, Guglielmino R, Carra G, "et al." |title=The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes. |journal=Haematologica |volume=87 |issue= 4 |pages= 434–42 |year= 2002 |pmid= 11940489 |doi=
*cite journal | author=Chua AO, Chizzonite R, Desai BB, "et al." |title=Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. |journal=J. Immunol. |volume=153 |issue= 1 |pages= 128–36 |year= 1994 |pmid= 7911493 |doi=
*cite journal | author=Andrew SE, Goldberg YP, Kremer B, "et al." |title=The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. |journal=Nat. Genet. |volume=4 |issue= 4 |pages= 398–403 |year= 1993 |pmid= 8401589 |doi= 10.1038/ng0893-398
*cite journal | author=Presky DH, Yang H, Minetti LJ, "et al." |title=A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14002–7 |year= 1997 |pmid= 8943050 |doi=
*cite journal | author=Zou J, Presky DH, Wu CY, Gubler U |title=Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 6073–7 |year= 1997 |pmid= 9038232 |doi=
*cite journal | author=Rogge L, Barberis-Maino L, Biffi M, "et al." |title=Selective expression of an interleukin-12 receptor component by human T helper 1 cells. |journal=J. Exp. Med. |volume=185 |issue= 5 |pages= 825–31 |year= 1997 |pmid= 9120388 |doi=
*cite journal | author=Yamamoto K, Kobayashi H, Miura O, "et al." |title=Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 257–8 |year= 1997 |pmid= 9284929 |doi=
*cite journal | author=Presky DH, Minetti LJ, Gillessen S, "et al." |title=Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. |journal=J. Immunol. |volume=160 |issue= 5 |pages= 2174–9 |year= 1998 |pmid= 9498755 |doi=
*cite journal | author=Morton SM, Bocaccio I, Depetris D, "et al." |title=Assignment of IL12RB2 to human chromosome 1p31.3-->p31.2 between D1S230 and D1S198. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 282–3 |year= 1998 |pmid= 9605872 |doi=
*cite journal | author=Naeger LK, McKinney J, Salvekar A, Hoey T |title=Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 1875–8 |year= 1999 |pmid= 9890938 |doi=
*cite journal | author=Yamamoto K, Shibata F, Miura O, "et al." |title=Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus. |journal=Biochem. Biophys. Res. Commun. |volume=257 |issue= 2 |pages= 400–4 |year= 1999 |pmid= 10198225 |doi= 10.1006/bbrc.1999.0479
*cite journal | author=Yao BB, Niu P, Surowy CS, Faltynek CR |title=Direct interaction of STAT4 with the IL-12 receptor. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 1 |pages= 147–55 |year= 1999 |pmid= 10415122 |doi= 10.1006/abbi.1999.1302
*cite journal | author=Matsui E, Kaneko H, Fukao T, "et al." |title=Mutations of the IL-12 receptor beta2 chain gene in atopic subjects. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 2 |pages= 551–5 |year= 2000 |pmid= 10600539 |doi= 10.1006/bbrc.1999.1859
*cite journal | author=van Rietschoten JG, Smits HH, Westland R, "et al." |title=Genomic organization of the human interleukin-12 receptor beta2-chain gene. |journal=Immunogenetics |volume=51 |issue= 1 |pages= 30–6 |year= 2000 |pmid= 10663559 |doi=
*cite journal | author=van Rietschoten JG, Smits HH, van de Wetering D, "et al." |title=Silencer activity of NFATc2 in the interleukin-12 receptor beta 2 proximal promoter in human T helper cells. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34509–16 |year= 2001 |pmid= 11438525 |doi= 10.1074/jbc.M102536200
*cite journal | author=Kim J, Uyemura K, Van Dyke MK, "et al." |title=A role for IL-12 receptor expression and signal transduction in host defense in leprosy. |journal=J. Immunol. |volume=167 |issue= 2 |pages= 779–86 |year= 2001 |pmid= 11441083 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jones ML, Young JM, Huang QR, "et al." |title=Interleukin 12-augmented T cell proliferation of peripheral blood mononuclear cells from HIV-seropositive individuals is associated with interleukin 12 receptor beta 2 upregulation. |journal=AIDS Res. Hum. Retroviruses |volume=19 |issue= 4 |pages= 283–92 |year= 2003 |pmid= 12804004 |doi= 10.1089/088922203764969483
*cite journal | author=Yamamoto K, Yamaguchi M, Miyasaka N, Miura O |title=SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 4 |pages= 1188–93 |year= 2003 |pmid= 14559241 |doi=

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