HTN3

Histatin 3, also known as HTN3, is a human gene.cite web | title = Entrez Gene: HTN3 histatin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3347| accessdate = ]

PBB_Summary
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summary_text = The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolyitic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity.cite web | title = Entrez Gene: HTN3 histatin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3347| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Troxler RF, Offner GD, Xu T, "et al." |title=Structural relationship between human salivary histatins. |journal=J. Dent. Res. |volume=69 |issue= 1 |pages= 2–6 |year= 1990 |pmid= 2303595 |doi=
*cite journal | author=vanderSpek JC, Offner GD, Troxler RF, Oppenheim FG |title=Molecular cloning of human submandibular histatins. |journal=Arch. Oral Biol. |volume=35 |issue= 2 |pages= 137–43 |year= 1990 |pmid= 2344289 |doi=
*cite journal | author=Sugiyama K, Ogino T, Ogata K |title=Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva. |journal=Arch. Oral Biol. |volume=35 |issue= 6 |pages= 415–9 |year= 1990 |pmid= 2372245 |doi=
*cite journal | author=Sabatini LM, Azen EA |title=Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). |journal=Biochem. Biophys. Res. Commun. |volume=160 |issue= 2 |pages= 495–502 |year= 1989 |pmid= 2719677 |doi=
*cite journal | author=vanderSpek JC, Wyandt HE, Skare JC, "et al." |title=Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. |journal=Am. J. Hum. Genet. |volume=45 |issue= 3 |pages= 381–7 |year= 1989 |pmid= 2773933 |doi=
*cite journal | author=Oppenheim FG, Xu T, McMillian FM, "et al." |title=Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. |journal=J. Biol. Chem. |volume=263 |issue= 16 |pages= 7472–7 |year= 1988 |pmid= 3286634 |doi=
*cite journal | author=Dickinson DP, Ridall AL, Levine MJ |title=Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence. |journal=Biochem. Biophys. Res. Commun. |volume=149 |issue= 2 |pages= 784–90 |year= 1988 |pmid= 3426601 |doi=
*cite journal | author=Sabatini LM, Azen EA |title=Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant. |journal=Hum. Mutat. |volume=4 |issue= 1 |pages= 12–9 |year= 1994 |pmid= 7951254 |doi= 10.1002/humu.1380040103
*cite journal | author=Sabatini LM, Ota T, Azen EA |title=Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. |journal=Mol. Biol. Evol. |volume=10 |issue= 3 |pages= 497–511 |year= 1993 |pmid= 8336540 |doi=
*cite journal | author=Tsai H, Raj PA, Bobek LA |title=Candidacidal activity of recombinant human salivary histatin-5 and variants. |journal=Infect. Immun. |volume=64 |issue= 12 |pages= 5000–7 |year= 1997 |pmid= 8945538 |doi=
*cite journal | author=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732–9 |year= 2000 |pmid= 10728974 |doi=
*cite journal | author=Naurato N, Wong P, Lu Y, "et al." |title=Interaction of tannin with human salivary histatins. |journal=J. Agric. Food Chem. |volume=47 |issue= 6 |pages= 2229–34 |year= 2000 |pmid= 10794615 |doi=
*cite journal | author=Gusman H, Travis J, Helmerhorst EJ, "et al." |title=Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. |journal=Infect. Immun. |volume=69 |issue= 3 |pages= 1402–8 |year= 2001 |pmid= 11179305 |doi= 10.1128/IAI.69.3.1402-1408.2001
*cite journal | author=Grogan J, McKnight CJ, Troxler RF, Oppenheim FG |title=Zinc and copper bind to unique sites of histatin 5. |journal=FEBS Lett. |volume=491 |issue= 1-2 |pages= 76–80 |year= 2001 |pmid= 11226423 |doi=
*cite journal | author=Gyurko C, Lendenmann U, Helmerhorst EJ, "et al." |title=Killing of Candida albicans by histatin 5: cellular uptake and energy requirement. |journal=Antonie Van Leeuwenhoek |volume=79 |issue= 3-4 |pages= 297–309 |year= 2002 |pmid= 11816973 |doi=
*cite journal | author=Baev D, Li XS, Dong J, "et al." |title=Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans. |journal=Infect. Immun. |volume=70 |issue= 9 |pages= 4777–84 |year= 2002 |pmid= 12183519 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Li XS, Reddy MS, Baev D, Edgerton M |title=Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28553–61 |year= 2003 |pmid= 12761219 |doi= 10.1074/jbc.M300680200
*cite journal | author=Ahmad M, Piludu M, Oppenheim FG, "et al." |title=Immunocytochemical localization of histatins in human salivary glands. |journal=J. Histochem. Cytochem. |volume=52 |issue= 3 |pages= 361–70 |year= 2004 |pmid= 14966203 |doi=
*cite journal | author=Castagnola M, Inzitari R, Rossetti DV, "et al." |title=A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41436–43 |year= 2004 |pmid= 15272024 |doi= 10.1074/jbc.M404322200

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