Granulocyte macrophage colony-stimulating factor receptor

Granulocyte macrophage colony-stimulating factor receptor

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.cite journal | author = Nicola NA, Metcalf D | title = Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells | journal = J. Cell. Physiol. | volume = 124 | issue = 2 | pages = 313–21 | year = 1985 | pmid = 3876343 | doi = 10.1002/jcp.1041240222 | issn = ]

tructure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor.cite journal | author = McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF | title = Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex | journal = Blood | volume = 101 | issue = 4 | pages = 1308–15 | year = 2003 | pmid = 12393492 | doi = 10.1182/blood-2002-06-1903 | issn = ] The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.cite journal | author = Geijsen N, Koenderman L, Coffer PJ | title = Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family | journal = Cytokine Growth Factor Rev. | volume = 12 | issue = 1 | pages = 19–25 | year = 2001 | pmid = 11312115 | doi = 10.1016/S1359-6101(00)00019-8 | issn = ]

ignal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family. This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.cite journal | author = Doyle SE, Gasson JC | title = Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5 | journal = Blood | volume = 92 | issue = 3 | pages = 867–76 | year = 1998 | pmid = 9680354 | doi = | issn = | url = http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;92/3/86 ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rappold G, Willson TA, Henke A, Gough NM |title=Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region. |journal=Genomics |volume=14 |issue= 2 |pages= 455–61 |year= 1992 |pmid= 1358805 |doi=
*cite journal | author=Hayashida K, Kitamura T, Gorman DM, "et al." |title=Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9655–9 |year= 1991 |pmid= 1702217 |doi=
*cite journal | author=Crosier KE, Wong GG, Mathey-Prevot B, "et al." |title=A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7744–8 |year= 1991 |pmid= 1715577 |doi=
*cite journal | author=Raines MA, Liu L, Quan SG, "et al." |title=Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 18 |pages= 8203–7 |year= 1991 |pmid= 1832774 |doi=
*cite journal | author=Gough NM, Gearing DP, Nicola NA, "et al." |title=Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region. |journal=Nature |volume=345 |issue= 6277 |pages= 734–6 |year= 1990 |pmid= 1972780 |doi= 10.1038/345734a0
*cite journal | author=Ashworth A, Kraft A |title=Cloning of a potentially soluble receptor for human GM-CSF. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7178 |year= 1991 |pmid= 2148207 |doi=
*cite journal | author=Gearing DP, King JA, Gough NM, Nicola NA |title=Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3667–76 |year= 1990 |pmid= 2555171 |doi=
*cite journal | author=DiPersio J, Billing P, Kaufman S, "et al." |title=Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. |journal=J. Biol. Chem. |volume=263 |issue= 4 |pages= 1834–41 |year= 1988 |pmid= 2828352 |doi=
*cite journal | author=Williams WV, VonFeldt JM, Rosenbaum H, "et al." |title=Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution. |journal=Arthritis Rheum. |volume=37 |issue= 10 |pages= 1468–78 |year= 1994 |pmid= 7945472 |doi=
*cite journal | author=Jubinsky PT, Laurie AS, Nathan DG, "et al." |title=Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit. |journal=Blood |volume=84 |issue= 12 |pages= 4174–85 |year= 1995 |pmid= 7994031 |doi=
*cite journal | author=Hu X, Emanuel PD, Zuckerman KS |title=Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor. |journal=Biochim. Biophys. Acta |volume=1223 |issue= 2 |pages= 306–8 |year= 1994 |pmid= 8086503 |doi=
*cite journal | author=Nakagawa Y, Kosugi H, Miyajima A, "et al." |title=Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10905–12 |year= 1994 |pmid= 8144676 |doi=
*cite journal | author=Zhao Y, Rong H, Chegini N |title=Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue. |journal=Biol. Reprod. |volume=53 |issue= 4 |pages= 923–30 |year= 1996 |pmid= 8547489 |doi=
*cite journal | author=Lia F, Rajotte D, Clark SC, Hoang T |title=A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex. |journal=J. Biol. Chem. |volume=271 |issue= 45 |pages= 28287–93 |year= 1996 |pmid= 8910448 |doi=
*cite journal | author=Wei S, Liu JH, Epling-Burnette PK, "et al." |title=Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. |journal=J. Immunol. |volume=157 |issue= 11 |pages= 5155–62 |year= 1996 |pmid= 8943427 |doi=
*cite journal | author=Soldi R, Primo L, Brizzi MF, "et al." |title=Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor. |journal=Blood |volume=89 |issue= 3 |pages= 863–72 |year= 1997 |pmid= 9028317 |doi=
*cite journal | author=Matsuguchi T, Zhao Y, Lilly MB, Kraft AS |title=The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17450–9 |year= 1997 |pmid= 9211889 |doi=
*cite journal | author=Rivas CI, Vera JC, Delgado-López F, "et al." |title=Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. |journal=Blood |volume=91 |issue= 3 |pages= 1037–43 |year= 1998 |pmid= 9446667 |doi=
*cite journal | author=Hu X, Zuckerman KS |title=Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein. |journal=Am. J. Hematol. |volume=58 |issue= 2 |pages= 145–7 |year= 1998 |pmid= 9625584 |doi=
*cite journal | author=Taha RA, Leung DY, Ghaffar O, "et al." |title=In vivo expression of cytokine receptor mRNA in atopic dermatitis. |journal=J. Allergy Clin. Immunol. |volume=102 |issue= 2 |pages= 245–50 |year= 1998 |pmid= 9723668 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Granulocyte macrophage colony-stimulating factor — Not to be confused with granulocyte colony stimulating factor. Colony stimulating factor 2 (granulocyte macrophage) PDB rendering based on 2gmf …   Wikipedia

  • granulocyte-macrophage colony-stimulating factor — n a colony stimulating factor produced by T cells, macrophages, endothelial cells, and fibroblasts that promotes the differentiation of bone marrow stem cells, stimulates the maturation of precursor cells into granulocytes and macrophages, and… …   Medical dictionary

  • Granulocyte colony-stimulating factor receptor — The granulocyte colony stimulating factor receptor (G CSF R) also known as CD114 (Cluster of Differentiation 114), is a cell surface receptor for the granulocyte colony stimulating factor (G CSF).cite web | title = Entrez Gene: CSF3R colony… …   Wikipedia

  • Macrophage colony-stimulating factor — Colony stimulating factor 1 (macrophage) PDB rendering based on 1hmc …   Wikipedia

  • Colony-stimulating factor — Colony stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate… …   Wikipedia

  • Granulocyte colony-stimulating factor — Not to be confused with granulocyte macrophage colony stimulating factor. Colony stimulating factor 3 (granulocyte) Crystal structure of 3 molecules of human G CSF. From PDB …   Wikipedia

  • Factor de crecimiento — Saltar a navegación, búsqueda Los factores de crecimiento o GF (degrowth factor) son un conjunto de sustancias, la mayoría de naturaleza proteica que junto con las hormonas y los neurotransmisores desempeñan una importante función en la… …   Wikipedia Español

  • Alveolar macrophage — Micrograph showing hemosiderin laden alveolar marcophages, as seen in a pulmonary haemorrhage. H E stain. An alveolar macrophage (or dust cell) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but separated from the… …   Wikipedia

  • Type I cytokine receptor — Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α helical strands. These receptors are also known under the name hemopoietin receptors, and share a common… …   Wikipedia

  • Fibroblast growth factor — Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin binding proteins and interactions with cell surface associated heparan sulfate… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”