Granulocyte colony-stimulating factor receptor

Granulocyte colony-stimulating factor receptor

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114), is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).cite web | title = Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)| url =| accessdate = ] The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction.

Th G-CSF receptors belongs to a family of cytokine receptors known as the "hematopoietin receptor family". Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.


The class IV isoform defective for both internalization and differentiation signaling.


ee also

* Cluster of differentiation

Further reading

citations =
*cite journal | author=Tsuji K, Ebihara Y |title=Expression of G-CSF receptor on myeloid progenitors. |journal=Leuk. Lymphoma |volume=42 |issue= 6 |pages= 1351–7 |year= 2002 |pmid= 11911419 |doi=
*cite journal | author=Kimura A, Sultana TA |title=Granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukemia. |journal=Leuk. Lymphoma |volume=45 |issue= 10 |pages= 1995–2000 |year= 2005 |pmid= 15370243 |doi= 10.1080/10428190410001714034
*cite journal | author=Tweardy DJ, Anderson K, Cannizzaro LA, "et al." |title=Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. |journal=Blood |volume=79 |issue= 5 |pages= 1148–54 |year= 1992 |pmid= 1371413 |doi=
*cite journal | author=Seto Y, Fukunaga R, Nagata S |title=Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor. |journal=J. Immunol. |volume=148 |issue= 1 |pages= 259–66 |year= 1992 |pmid= 1530796 |doi=
*cite journal | author=Fukunaga R, Seto Y, Mizushima S, Nagata S |title=Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8702–6 |year= 1991 |pmid= 1701053 |doi=
*cite journal | author=Fukunaga R, Ishizaka-Ikeda E, Pan CX, "et al." |title=Functional domains of the granulocyte colony-stimulating factor receptor. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2855–65 |year= 1991 |pmid= 1717255 |doi=
*cite journal | author=Inazawa J, Fukunaga R, Seto Y, "et al." |title=Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3. |journal=Genomics |volume=10 |issue= 4 |pages= 1075–8 |year= 1991 |pmid= 1833306 |doi=
*cite journal | author=Larsen A, Davis T, Curtis BM, "et al." |title=Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains. |journal=J. Exp. Med. |volume=172 |issue= 6 |pages= 1559–70 |year= 1991 |pmid= 2147944 |doi=
*cite journal | author=Uzumaki H, Okabe T, Sasaki N, "et al." |title=Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9323–6 |year= 1990 |pmid= 2480598 |doi=
*cite journal | author=Nicholson SE, Oates AC, Harpur AG, "et al." |title=Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 2985–8 |year= 1994 |pmid= 7512720 |doi=
*cite journal | author=Dong F, Hoefsloot LH, Schelen AM, "et al." |title=Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 10 |pages= 4480–4 |year= 1994 |pmid= 7514305 |doi=
*cite journal | author=Dong F, Brynes RK, Tidow N, "et al." |title=Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. |journal=N. Engl. J. Med. |volume=333 |issue= 8 |pages= 487–93 |year= 1995 |pmid= 7542747 |doi=
*cite journal | author=Shimoda K, Okamura S, Harada N, "et al." |title=Identification of a functional receptor for granulocyte colony-stimulating factor on platelets. |journal=J. Clin. Invest. |volume=91 |issue= 4 |pages= 1310–3 |year= 1993 |pmid= 7682568 |doi=
*cite journal | author=Zhao Y, Wagner F, Frank SJ, Kraft AS |title=The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. |journal=J. Biol. Chem. |volume=270 |issue= 23 |pages= 13814–8 |year= 1995 |pmid= 7775438 |doi=
*cite journal | author=Corey SJ, Burkhardt AL, Bolen JB, "et al." |title=Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 11 |pages= 4683–7 |year= 1994 |pmid= 8197119 |doi=
*cite journal | author=Haniu M, Horan T, Arakawa T, "et al." |title=Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region. |journal=Arch. Biochem. Biophys. |volume=324 |issue= 2 |pages= 344–56 |year= 1996 |pmid= 8554326 |doi= 10.1006/abbi.1995.0047
*cite journal | author=Horan T, Wen J, Narhi L, "et al." |title=Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes. |journal=Biochemistry |volume=35 |issue= 15 |pages= 4886–96 |year= 1996 |pmid= 8664280 |doi= 10.1021/bi9525841
*cite journal | author=McCracken S, Layton JE, Shorter SC, "et al." |title=Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta. |journal=J. Endocrinol. |volume=149 |issue= 2 |pages= 249–58 |year= 1996 |pmid= 8708536 |doi=
*cite journal | author=Haniu M, Horan T, Arakawa T, "et al." |title=Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor. |journal=Biochemistry |volume=35 |issue= 40 |pages= 13040–6 |year= 1996 |pmid= 8855939 |doi= 10.1021/bi960213u
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=

External links


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