CX3CR1

Only one member belongs to the CX₃C sub-family of chemokine receptors - CX₃CR1. As the name suggests, this receptor binds the chemokine CX3CL1 (also called neurotactin or fractalkine).

Expression of this receptor appears to be associated with lymphocytes. [Imai et al. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521-530, 1997. ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173–83 |year= 2002 |pmid= 11818437 |doi=
*cite journal | author=Raport CJ, Schweickart VL, Eddy RL, "et al." |title=The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. |journal=Gene |volume=163 |issue= 2 |pages= 295–9 |year= 1995 |pmid= 7590284 |doi=
*cite journal | author=Combadiere C, Ahuja SK, Murphy PM |title=Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. |journal=DNA Cell Biol. |volume=14 |issue= 8 |pages= 673–80 |year= 1995 |pmid= 7646814 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Imai T, Hieshima K, Haskell C, "et al." |title=Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. |journal=Cell |volume=91 |issue= 4 |pages= 521–30 |year= 1997 |pmid= 9390561 |doi=
*cite journal | author=Combadiere C, Salzwedel K, Smith ED, "et al." |title=Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23799–804 |year= 1998 |pmid= 9726990 |doi=
*cite journal | author=Mizoue LS, Bazan JF, Johnson EC, Handel TM |title=Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. |journal=Biochemistry |volume=38 |issue= 5 |pages= 1402–14 |year= 1999 |pmid= 9931005 |doi= 10.1021/bi9820614
*cite journal | author=Maho A, Bensimon A, Vassart G, Parmentier M |title=Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 265–8 |year= 2000 |pmid= 10702689 |doi=
*cite journal | author=Faure S, Meyer L, Costagliola D, "et al." |title=Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. |journal=Science |volume=287 |issue= 5461 |pages= 2274–7 |year= 2000 |pmid= 10731151 |doi=
*cite journal | author=Yoneda O, Imai T, Goda S, "et al." |title=Fractalkine-mediated endothelial cell injury by NK cells. |journal=J. Immunol. |volume=164 |issue= 8 |pages= 4055–62 |year= 2000 |pmid= 10754298 |doi=
*cite journal | author=Meucci O, Fatatis A, Simen AA, Miller RJ |title=Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 8075–80 |year= 2000 |pmid= 10869418 |doi= 10.1073/pnas.090017497
*cite journal | author=Papadopoulos EJ, Fitzhugh DJ, Tkaczyk C, "et al." |title=Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2355–61 |year= 2000 |pmid= 10940926 |doi=
*cite journal | author=Moatti D, Faure S, Fumeron F, "et al." |title=Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease. |journal=Blood |volume=97 |issue= 7 |pages= 1925–8 |year= 2001 |pmid= 11264153 |doi=
*cite journal | author=Foussat A, Bouchet-Delbos L, Berrebi D, "et al." |title=Deregulation of the expression of the fractalkine/fractalkine receptor complex in HIV-1-infected patients. |journal=Blood |volume=98 |issue= 6 |pages= 1678–86 |year= 2001 |pmid= 11535497 |doi=
*cite journal | author=Dichmann S, Herouy Y, Purlis D, "et al." |title=Fractalkine induces chemotaxis and actin polymerization in human dendritic cells. |journal=Inflamm. Res. |volume=50 |issue= 11 |pages= 529–33 |year= 2002 |pmid= 11766992 |doi=
*cite journal | author=Brand S, Sakaguchi T, Gu X, "et al." |title=Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. |journal=Gastroenterology |volume=122 |issue= 1 |pages= 166–77 |year= 2002 |pmid= 11781291 |doi=
*cite journal | author=Utaipat U, Duerr A, Rudolph DL, "et al." |title=Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11804551 |doi= 10.1089/088922202753394664
*cite journal | author=Fong AM, Alam SM, Imai T, "et al." |title=CX3CR1 tyrosine sulfation enhances fractalkine-induced cell adhesion. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19418–23 |year= 2002 |pmid= 11909868 |doi= 10.1074/jbc.M201396200

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes