Death-inducing signaling complex
- Death-inducing signaling complex
-
Signaling pathway of
TNF-R1. Dashed grey lines represent multiple steps
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors.[1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase 8. It transduces a downstream signal cascade resulting in apoptosis.
References
- ^ Kischkel, FC; Hellbardt, S, Behrmann, I, Germer, M, Pawlita, M, Krammer, PH, Peter, ME (1995 Nov 15). "Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.". The EMBO journal 14 (22): 5579–88. PMID 8521815.
External links
| v · d · eApoptosis signaling pathway |
|
| Fas path |
|
|
| TNF path |
|
|
| Other |
|
|
| B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp) |
|
Wikimedia Foundation.
2010.
Look at other dictionaries:
Death-associated protein 6 — Death domain associated protein Identifiers Symbols DAXX; BING2; DAP6; EAP1; MGC126245; MGC126246 External IDs … Wikipedia
Apoptosis — (IPA en|ˌæpəpˈtoʊsəs [ [http://www.webster.com/dictionary/apoptosis Webster.com dictionary entry] ] ) is a form of programmed cell death in multicellular organisms. It is one of the main types of programmed cell death (PCD) and involves a series… … Wikipedia
Caspase-9 — Caspase 9, apoptosis related cysteine peptidase PDB rendering based on 1jxq … Wikipedia
Cytochrome c — Cytochrome c, somatic Three dimensional structure of cytochrome c (green) with a heme molecule coordinating a central Iron atom (orange) … Wikipedia
RIPK1 — Receptor (TNFRSF) interacting serine threonine kinase 1, also known as RIPK1, is a human gene.cite web | title = Entrez Gene: RIPK1 receptor (TNFRSF) interacting serine threonine kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
Tumor necrosis factor receptor — TNFR/NGFR cysteine rich region Structure of the soluble human 55 kd TNF receptor human TNF beta complex[1]. Identifiers Symbol … Wikipedia
MYD88 — Myeloid differentiation primary response gene (88) Signaling pathway of toll like receptors. Dashed grey lines represent unknown associations … Wikipedia
Cortactin — PDB rendering based on 1x69 … Wikipedia
PEA15 — Phosphoprotein enriched in astrocytes 15 PDB rendering based on 1n3k … Wikipedia
SMAD (protein) — SMADs are intracellular proteins that transduce extracellular signals from transforming growth factor beta ligands to the nucleus where they activate downstream TGF β gene transcription.[1][2][3][4][5] … Wikipedia
