TRADD

TRADD

TNFRSF1A-associated via death domain, also known as TRADD, is a human gene.cite web | title = Entrez Gene: TRADD TNFRSF1A-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8717| accessdate = ]

TRADD is an adaptor protein.

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summary_text = The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.cite web | title = Entrez Gene: TRADD TNFRSF1A-associated via death domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8717| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Baker SJ, Reddy EP |title=Modulation of life and death by the TNF receptor superfamily. |journal=Oncogene |volume=17 |issue= 25 |pages= 3261–70 |year= 1999 |pmid= 9916988 |doi= 10.1038/sj.onc.1202568
*cite journal | author=Hsu H, Xiong J, Goeddel DV |title=The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. |journal=Cell |volume=81 |issue= 4 |pages= 495–504 |year= 1995 |pmid= 7758105 |doi=
*cite journal | author=Hsu H, Shu HB, Pan MG, Goeddel DV |title=TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |journal=Cell |volume=84 |issue= 2 |pages= 299–308 |year= 1996 |pmid= 8565075 |doi=
*cite journal | author=Hsu H, Huang J, Shu HB, "et al." |title=TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. |journal=Immunity |volume=4 |issue= 4 |pages= 387–96 |year= 1996 |pmid= 8612133 |doi=
*cite journal | author=Boldin MP, Goncharov TM, Goltsev YV, Wallach D |title=Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. |journal=Cell |volume=85 |issue= 6 |pages= 803–15 |year= 1996 |pmid= 8681376 |doi=
*cite journal | author=Takeuchi M, Rothe M, Goeddel DV |title=Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19935–42 |year= 1996 |pmid= 8702708 |doi=
*cite journal | author=Kitson J, Raven T, Jiang YP, "et al." |title=A death-domain-containing receptor that mediates apoptosis. |journal=Nature |volume=384 |issue= 6607 |pages= 372–5 |year= 1996 |pmid= 8934525 |doi= 10.1038/384372a0
*cite journal | author=Shu HB, Takeuchi M, Goeddel DV |title=The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13973–8 |year= 1997 |pmid= 8943045 |doi=
*cite journal | author=Izumi KM, Kieff ED |title=The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 23 |pages= 12592–7 |year= 1997 |pmid= 9356494 |doi=
*cite journal | author=Wajant H, Johannes FJ, Haas E, "et al." |title=Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction. |journal=Curr. Biol. |volume=8 |issue= 2 |pages= 113–6 |year= 1998 |pmid= 9427646 |doi=
*cite journal | author=Chaudhary PM, Eby M, Jasmin A, "et al." |title=Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. |journal=Immunity |volume=7 |issue= 6 |pages= 821–30 |year= 1998 |pmid= 9430227 |doi=
*cite journal | author=Pan G, Bauer JH, Haridas V, "et al." |title=Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. |journal=FEBS Lett. |volume=431 |issue= 3 |pages= 351–6 |year= 1998 |pmid= 9714541 |doi=
*cite journal | author=Jones SJ, Ledgerwood EC, Prins JB, "et al." |title=TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1. |journal=J. Immunol. |volume=162 |issue= 2 |pages= 1042–8 |year= 1999 |pmid= 9916731 |doi=
*cite journal | author=Schütze S, Machleidt T, Adam D, "et al." |title=Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10203–12 |year= 1999 |pmid= 10187805 |doi=
*cite journal | author=Sanz L, Sanchez P, Lallena MJ, "et al." |title=The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3044–53 |year= 1999 |pmid= 10356400 |doi= 10.1093/emboj/18.11.3044
*cite journal | author=Costanzo A, Guiet C, Vito P |title=c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20127–32 |year= 1999 |pmid= 10400625 |doi=
*cite journal | author=Wang Y, Wu TR, Cai S, "et al." |title=Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4505–12 |year= 2000 |pmid= 10848577 |doi=
*cite journal | author=Park YC, Ye H, Hsia C, "et al." |title=A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. |journal=Cell |volume=101 |issue= 7 |pages= 777–87 |year= 2000 |pmid= 10892748 |doi=
*cite journal | author=Tsao DH, McDonagh T, Telliez JB, "et al." |title=Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1051–7 |year= 2000 |pmid= 10911999 |doi=

External links

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