TRAF3

TNF receptor-associated factor 3, also known as TRAF3, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [cite web | title = Entrez Gene: TRAF3 TNF receptor-associated factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7187| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=
*cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788
*cite journal | author=Saha SK, Cheng G |title=TRAF3: a new regulator of type I interferons. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 804–7 |year= 2006 |pmid= 16582590 |doi=
*cite journal | author=Hu HM, O'Rourke K, Boguski MS, Dixit VM |title=A novel RING finger protein interacts with the cytoplasmic domain of CD40. |journal=J. Biol. Chem. |volume=269 |issue= 48 |pages= 30069–72 |year= 1994 |pmid= 7527023 |doi=
*cite journal | author=Sato T, Irie S, Reed JC |title=A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. |journal=FEBS Lett. |volume=358 |issue= 2 |pages= 113–8 |year= 1995 |pmid= 7530216 |doi=
*cite journal | author=Cheng G, Cleary AM, Ye ZS, "et al." |title=Involvement of CRAF1, a relative of TRAF, in CD40 signaling. |journal=Science |volume=267 |issue= 5203 |pages= 1494–8 |year= 1995 |pmid= 7533327 |doi=
*cite journal | author=Mosialos G, Birkenbach M, Yalamanchili R, "et al." |title=The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. |journal=Cell |volume=80 |issue= 3 |pages= 389–99 |year= 1995 |pmid= 7859281 |doi=
*cite journal | author=Hsu H, Shu HB, Pan MG, Goeddel DV |title=TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |journal=Cell |volume=84 |issue= 2 |pages= 299–308 |year= 1996 |pmid= 8565075 |doi=
*cite journal | author=Hsu H, Huang J, Shu HB, "et al." |title=TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. |journal=Immunity |volume=4 |issue= 4 |pages= 387–96 |year= 1996 |pmid= 8612133 |doi=
*cite journal | author=Butch ER, Guan KL |title=Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4230–5 |year= 1996 |pmid= 8626767 |doi=
*cite journal | author=Gedrich RW, Gilfillan MC, Duckett CS, "et al." |title=CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 12852–8 |year= 1996 |pmid= 8662842 |doi=
*cite journal | author=Nakano H, Oshima H, Chung W, "et al." |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661–4 |year= 1996 |pmid= 8663299 |doi=
*cite journal | author=Rothe M, Xiong J, Shu HB, "et al." |title=I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8241–6 |year= 1996 |pmid= 8710854 |doi=
*cite journal | author=Hubberstey A, Yu G, Loewith R, "et al." |title=Mammalian CAP interacts with CAP, CAP2, and actin. |journal=J. Cell. Biochem. |volume=61 |issue= 3 |pages= 459–66 |year= 1997 |pmid= 8761950 |doi= 10.1002/(SICI)1097-4644(19960601)61:3<459::AID-JCB13>3.0.CO;2-E
*cite journal | author=Ansieau S, Scheffrahn I, Mosialos G, "et al." |title=Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14053–8 |year= 1997 |pmid= 8943059 |doi=
*cite journal | author=VanArsdale TL, VanArsdale SL, Force WR, "et al." |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2460–5 |year= 1997 |pmid= 9122217 |doi=
*cite journal | author=Marsters SA, Ayres TM, Skubatch M, "et al." |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14029–32 |year= 1997 |pmid= 9162022 |doi=
*cite journal | author=Boucher LM, Marengère LE, Lu Y, "et al." |title=Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 3 |pages= 592–600 |year= 1997 |pmid= 9168896 |doi= 10.1006/bbrc.1997.6509
*cite journal | author=Song HY, Régnier CH, Kirschning CJ, "et al." |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792–6 |year= 1997 |pmid= 9275204 |doi=
*cite journal | author=Force WR, Cheung TC, Ware CF |title=Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30835–40 |year= 1998 |pmid= 9388227 |doi=

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