TGF beta receptor 2

Transforming growth factor, beta receptor II (70/80kDa)
PDB rendering based on 1ktz.
Available structures PDB 1KTZ, 1M9Z, 1PLO, 2PJY, 3KFD
Identifiers
Symbols	TGFBR2; AAT3; FAA3; LDS1B; LDS2B; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
External IDs	OMIM: 190182 MGI: 98729 HomoloGene: 2435 GeneCards: TGFBR2 Gene
EC number	2.7.11.30
Gene Ontology Molecular function • nucleotide binding • transmembrane receptor protein serine/threonine kinase activity • receptor signaling protein serine/threonine kinase activity • receptor activity • transforming growth factor beta receptor activity • transforming growth factor beta receptor activity • transforming growth factor beta receptor activity • transforming growth factor beta receptor activity, type II • protein binding • protein binding • ATP binding • glycosaminoglycan binding • type I transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • type III transforming growth factor beta receptor binding • SMAD binding • metal ion binding • transforming growth factor beta binding • transforming growth factor beta binding Cellular component • plasma membrane • plasma membrane • caveola • external side of plasma membrane • integral to membrane • receptor complex • transforming growth factor beta receptor complex Biological process • blood vessel development • patterning of blood vessels • vasculogenesis • positive regulation of mesenchymal cell proliferation • positive regulation of tolerance induction to self antigen • positive regulation of B cell tolerance induction • positive regulation of T cell tolerance induction • protein phosphorylation • transforming growth factor beta receptor signaling pathway • transforming growth factor beta receptor signaling pathway • transforming growth factor beta receptor signaling pathway • transforming growth factor beta receptor signaling pathway • brain development • heart development • positive regulation of cell proliferation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • activation of protein kinase activity • embryonic hemopoiesis • regulation of cell proliferation • response to drug • myeloid dendritic cell differentiation • embryonic cranial skeleton morphogenesis • positive regulation of NK T cell differentiation • palate development • pathway-restricted SMAD protein phosphorylation • response to cholesterol • positive regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7048	21813
Ensembl	ENSG00000163513	ENSMUSG00000032440
UniProt	P37173	Q9JLZ4
RefSeq (mRNA)	NM_001024847.2	NM_009371
RefSeq (protein)	NP_001020018.1	NP_033397
Location (UCSC)	Chr 3: 30.65 – 30.74 Mb	Chr 9: 115.99 – 116.08 Mb
PubMed search	[1]	[2]

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene.

It is a tumor suppressor gene.^[1]

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.^[2]

Interactions

TGF beta receptor 2 has been shown to interact with Cyclin B2,^[3] TGF beta receptor 1,^[4][5] Transforming growth factor, beta 3,^[6][7][8][9] AP2B1,^[10] Endoglin,^[8][11] Heat shock protein 90kDa alpha (cytosolic), member A1^[12] and STRAP.^[13][14]

Domain architecture

Transforming growth factor beta receptor 2 ectodomain
crystal structure of human tgf-beta type ii receptor ligand binding domain
Identifiers
Symbol	ecTbetaR2
Pfam	PF08917
InterPro	IPR015013
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

TGF beta receptor 2 consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9).^[7]

See also

• TGF beta receptors

External links

• GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections

References

1. ^ "TGFBR2 - transforming growth factor, beta receptor II (70/80kDa) - Genetics Home Reference". http://ghr.nlm.nih.gov/gene=tgfbr2. Retrieved 2008-09-07. 
2. ^ "Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7048. 
3. ^ Liu, J H; Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y (Jan. 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene (ENGLAND) 18 (1): 269–75. doi:10.1038/sj.onc.1202263. ISSN 0950-9232. PMID 9926943. 
4. ^ Kawabata, M; Chytil A, Moses H L (Mar. 1995). "Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor". J. Biol. Chem. (UNITED STATES) 270 (10): 5625–30. doi:10.1074/jbc.270.10.5625. ISSN 0021-9258. PMID 7890683. 
5. ^ Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. 2001). "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor". J. Biol. Chem. (United States) 276 (9): 6727–38. doi:10.1074/jbc.M008340200. ISSN 0021-9258. PMID 11102446. 
6. ^ De Crescenzo, Gregory; Pham Phuong L, Durocher Yves, O'Connor-McCourt Maureen D (May. 2003). "Transforming growth factor-beta (TGF-beta) binding to the extracellular domain of the type II TGF-beta receptor: receptor capture on a biosensor surface using a new coiled-coil capture system demonstrates that avidity contributes significantly to high affinity binding". J. Mol. Biol. (England) 328 (5): 1173–83. doi:10.1016/S0022-2836(03)00360-7. ISSN 0022-2836. PMID 12729750. 
7. ^ ^{a b} Hart, P John; Deep Shashank, Taylor Alexander B, Shu Zhanyong, Hinck Cynthia S, Hinck Andrew P (Mar. 2002). "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex". Nat. Struct. Biol. (United States) 9 (3): 203–8. doi:10.1038/nsb766. ISSN 1072-8368. PMID 11850637. 
8. ^ ^{a b} Barbara, N P; Wrana J L, Letarte M (Jan. 1999). "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily". J. Biol. Chem. (UNITED STATES) 274 (2): 584–94. doi:10.1074/jbc.274.2.584. ISSN 0021-9258. PMID 9872992. 
9. ^ Rotzer, D; Roth M, Lutz M, Lindemann D, Sebald W, Knaus P (Feb. 2001). "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor". EMBO J. (England) 20 (3): 480–90. doi:10.1093/emboj/20.3.480. ISSN 0261-4189. PMC 133482. PMID 11157754. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133482. 
10. ^ Yao, Diying; Ehrlich Marcelo, Henis Yoav I, Leof Edward B (Nov. 2002). "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit". Mol. Biol. Cell (United States) 13 (11): 4001–12. doi:10.1091/mbc.02-07-0104. ISSN 1059-1524. PMC 133610. PMID 12429842. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133610. 
11. ^ Guerrero-Esteo, Mercedes; Sanchez-Elsner Tilman, Letamendia Ainhoa, Bernabeu Carmelo (Aug. 2002). "Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II". J. Biol. Chem. (United States) 277 (32): 29197–209. doi:10.1074/jbc.M111991200. ISSN 0021-9258. PMID 12015308. 
12. ^ Wrighton, Katharine H; Lin Xia, Feng Xin-Hua (Jul. 2008). "Critical regulation of TGFbeta signaling by Hsp90". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (27): 9244–9. doi:10.1073/pnas.0800163105. PMC 2453700. PMID 18591668. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2453700. 
13. ^ Datta, P K; Chytil A, Gorska A E, Moses H L (Dec. 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. (UNITED STATES) 273 (52): 34671–4. doi:10.1074/jbc.273.52.34671. ISSN 0021-9258. PMID 9856985. 
14. ^ Datta, P K; Moses H L (May. 2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling". Mol. Cell. Biol. (UNITED STATES) 20 (9): 3157–67. doi:10.1128/MCB.20.9.3157-3167.2000. ISSN 0270-7306. PMC 85610. PMID 10757800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85610. 

This article includes text from the public domain Pfam and InterPro IPR015013