Chemokine (C-C motif) receptor 2

Rendering based on PDB 1KAD.
Symbols CCR2; CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1-R; MGC103828; MGC111760; MGC168006
External IDs OMIM601267 MGI106185 HomoloGene537 IUPHAR: CCR2 GeneCards: CCR2 Gene
Species Human Mouse
Entrez 729230 12772
Ensembl ENSG00000121807 ENSMUSG00000049103
UniProt P41597 Q3TRK1
RefSeq (mRNA) NM_001123041.2 NM_009915.2
RefSeq (protein) NP_001116513.2 NP_034045.1
Location (UCSC) Chr 3:
46.4 – 46.4 Mb
Chr 9:
124.02 – 124.03 Mb
PubMed search [1] [2]

CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor.

CCR2 has also recently been designated CD192 (cluster of differentiation 192).

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.[1]

See also


Further reading

  • Sozzani S, Introna M, Bernasconi S et al. (1997). "MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression". J. Leukoc. Biol. 62 (1): 30–3. PMID 9225989. 
  • Choe H, Martin KA, Farzan M et al. (1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Semin. Immunol. 10 (3): 249–57. doi:10.1006/smim.1998.0127. PMID 9653051. 
  • Cunningham AL, Li S, Juarez J et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245. 
  • Ruibal-Ares BH, Belmonte L, Baré PC et al. (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339. 
  • Yamagami S, Tokuda Y, Ishii K et al. (1994). "cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor". Biochem. Biophys. Res. Commun. 202 (2): 1156–62. doi:10.1006/bbrc.1994.2049. PMID 8048929. 
  • Charo IF, Myers SJ, Herman A et al. (1994). "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2752–6. doi:10.1073/pnas.91.7.2752. PMC 43448. PMID 8146186. 
  • Combadiere C, Ahuja SK, Van Damme J et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B". J. Biol. Chem. 270 (50): 29671–5. doi:10.1074/jbc.270.50.29671. PMID 8530354. 
  • Samson M, Soularue P, Vassart G, Parmentier M (1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276. 
  • Wong LM, Myers SJ, Tsou CL et al. (1997). "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking". J. Biol. Chem. 272 (2): 1038–45. doi:10.1074/jbc.272.2.1038. PMID 8995400. 
  • Polentarutti N, Allavena P, Bianchi G et al. (1997). "IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences". J. Immunol. 158 (6): 2689–94. PMID 9058802. 
  • Gong X, Gong W, Kuhns DB et al. (1997). "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors". J. Biol. Chem. 272 (18): 11682–5. doi:10.1074/jbc.272.18.11682. PMID 9115216. 
  • Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512. 
  • Berkhout TA, Sarau HM, Moores K et al. (1997). "Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B". J. Biol. Chem. 272 (26): 16404–13. doi:10.1074/jbc.272.26.16404. PMID 9195948. 
  • Smith MW, Dean M, Carrington M et al. (1997). "Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study". Science 277 (5328): 959–65. doi:10.1126/science.277.5328.959. PMID 9252328. 
  • Monteclaro FS, Charo IF (1997). "The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by a pseudo-tethered ligand". J. Biol. Chem. 272 (37): 23186–90. doi:10.1074/jbc.272.37.23186. PMID 9287323. 
  • Aragay AM, Mellado M, Frade JM et al. (1998). "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2985–90. doi:10.1073/pnas.95.6.2985. PMC 19681. PMID 9501202. 
  • Frade JM, Mellado M, del Real G et al. (1998). "Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells". J. Immunol. 159 (11): 5576–84. PMID 9548499. 
  • Mummidi S, Ahuja SS, Gonzalez E et al. (1999). "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression". Nat. Med. 4 (7): 786–93. doi:10.1038/nm0798-786. PMID 9662369. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TNF receptor JAK-STAT Ig superfamily
CSF1 · KIT · IL1 (IL1R1, IL1R2· IL18R/IL18R1
IL-17 family
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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