CCR2

Chemokine (C-C motif) receptor 2
Rendering based on PDB 1KAD.
Available structures PDB 1KAD, 1KP1
Identifiers
Symbols	CCR2; CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; FLJ78302; MCP-1-R; MGC103828; MGC111760; MGC168006
External IDs	OMIM: 601267 MGI: 106185 HomoloGene: 537 IUPHAR: CCR2 GeneCards: CCR2 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • chemokine receptor activity • C-C chemokine receptor activity • CCR2 chemokine receptor binding • protein homodimerization activity Cellular component • soluble fraction • cytoplasm • cytosol • plasma membrane • plasma membrane • plasma membrane • integral to plasma membrane • integral to membrane • dendrite • neuronal cell body • perikaryon • perinuclear region of cytoplasm Biological process • blood vessel remodeling • dendritic cell chemotaxis • positive regulation of T-helper 1 type immune response • negative regulation of type 2 immune response • cellular calcium ion homeostasis • chemotaxis • inflammatory response • immune response • cellular defense response • negative regulation of adenylate cyclase activity • elevation of cytosolic calcium ion concentration • JAK-STAT cascade • response to wounding • regulation of vascular endothelial growth factor production • positive regulation of T cell chemotaxis • negative regulation of angiogenesis • cytokine-mediated signaling pathway • cellular homeostasis • positive regulation of cell migration • positive regulation of interferon-gamma production • positive regulation of interleukin-2 production • monocyte extravasation • T-helper 17 cell chemotaxis • positive regulation of tumor necrosis factor biosynthetic process • negative regulation of eosinophil degranulation • astrocyte cell migration • interspecies interaction between organisms • positive regulation of alpha-beta T cell proliferation • positive regulation of inflammatory response • positive regulation of T cell activation • chemokine-mediated signaling pathway • positive regulation of monocyte chemotaxis • positive regulation of immune complex clearance by monocytes and macrophages • positive regulation of T cell extravasation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	729230	12772
Ensembl	ENSG00000121807	ENSMUSG00000049103
UniProt	P41597	Q3TRK1
RefSeq (mRNA)	NM_001123041.2	NM_009915.2
RefSeq (protein)	NP_001116513.2	NP_034045.1
Location (UCSC)	Chr 3: 46.4 – 46.4 Mb	Chr 9: 124.02 – 124.03 Mb
PubMed search	[1]	[2]

CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor.

CCR2 has also recently been designated CD192 (cluster of differentiation 192).

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.^[1]

See also

• CC chemokine receptors
• Cluster of differentiation

References

1. ^ "Entrez Gene: CCR2 chemokine (C-C motif) receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1231. 

Further reading

• Sozzani S, Introna M, Bernasconi S et al. (1997). "MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression". J. Leukoc. Biol. 62 (1): 30–3. PMID 9225989. 
• Choe H, Martin KA, Farzan M et al. (1998). "Structural interactions between chemokine receptors, gp120 Env and CD4". Semin. Immunol. 10 (3): 249–57. doi:10.1006/smim.1998.0127. PMID 9653051. 
• Cunningham AL, Li S, Juarez J et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes". J. Leukoc. Biol. 68 (3): 311–7. PMID 10985245. 
• Ruibal-Ares BH, Belmonte L, Baré PC et al. (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339. 
• Yamagami S, Tokuda Y, Ishii K et al. (1994). "cDNA cloning and functional expression of a human monocyte chemoattractant protein 1 receptor". Biochem. Biophys. Res. Commun. 202 (2): 1156–62. doi:10.1006/bbrc.1994.2049. PMID 8048929. 
• Charo IF, Myers SJ, Herman A et al. (1994). "Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2752–6. doi:10.1073/pnas.91.7.2752. PMC 43448. PMID 8146186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43448. 
• Combadiere C, Ahuja SK, Van Damme J et al. (1996). "Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B". J. Biol. Chem. 270 (50): 29671–5. doi:10.1074/jbc.270.50.29671. PMID 8530354. 
• Samson M, Soularue P, Vassart G, Parmentier M (1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276. 
• Wong LM, Myers SJ, Tsou CL et al. (1997). "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking". J. Biol. Chem. 272 (2): 1038–45. doi:10.1074/jbc.272.2.1038. PMID 8995400. 
• Polentarutti N, Allavena P, Bianchi G et al. (1997). "IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences". J. Immunol. 158 (6): 2689–94. PMID 9058802. 
• Gong X, Gong W, Kuhns DB et al. (1997). "Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors". J. Biol. Chem. 272 (18): 11682–5. doi:10.1074/jbc.272.18.11682. PMID 9115216. 
• Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512. 
• Berkhout TA, Sarau HM, Moores K et al. (1997). "Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B". J. Biol. Chem. 272 (26): 16404–13. doi:10.1074/jbc.272.26.16404. PMID 9195948. 
• Smith MW, Dean M, Carrington M et al. (1997). "Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study". Science 277 (5328): 959–65. doi:10.1126/science.277.5328.959. PMID 9252328. 
• Monteclaro FS, Charo IF (1997). "The amino-terminal domain of CCR2 is both necessary and sufficient for high affinity binding of monocyte chemoattractant protein 1. Receptor activation by a pseudo-tethered ligand". J. Biol. Chem. 272 (37): 23186–90. doi:10.1074/jbc.272.37.23186. PMID 9287323. 
• Aragay AM, Mellado M, Frade JM et al. (1998). "Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2985–90. doi:10.1073/pnas.95.6.2985. PMC 19681. PMID 9501202. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19681. 
• Frade JM, Mellado M, del Real G et al. (1998). "Characterization of the CCR2 chemokine receptor: functional CCR2 receptor expression in B cells". J. Immunol. 159 (11): 5576–84. PMID 9548499. 
• Mummidi S, Ahuja SS, Gonzalez E et al. (1999). "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression". Nat. Med. 4 (7): 786–93. doi:10.1038/nm0798-786. PMID 9662369. 

External links

• "Chemokine Receptors: CCR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2222. 
• MeSH CCR2+protein,+human
• description at Information Hyperlinked Over Proteins

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TNF receptor

1-10	TNFRSF1 (CD120) · TNFRSF1A (CD120a) · TNFRSF1B (CD120b) · TNFRSF3 (Lymphotoxin beta receptor) · TNFRSF4 (CD134) · TNFRSF5 (CD40) · TNFRSF6 (FAS) · TNFRSF6B · TNFRSF7 (CD27) · TNFRSF8 (CD30) · TNFRSF9 (CD137)
11-20	TNFRSF10A (CD261) · TNFRSF10B (CD262) · TNFRSF10C (CD263) · TNFRSF10D (CD264) · TNFRSF11A (CD265/RANK) · TNFRSF11B (Osteoprotegerin) · TNFRSF12A (CD266) · TNFRSF13B (CD267) · TNFRSF13C · TNFRSF14 (CD268) · TNFRSF16 (Nerve growth factor receptor) · TNFRSF17 (CD269) · TNFRSF18 · TNFRSF19
21-25	TNFRSF21 · TNFRSF25 · TNFRSF27

JAK-STAT

Type I	γ-chain Interleukin receptors (IL2R/IL2RA/IL2RB/IL15R, IL4R/IL13R/IL13RA1/IL13RA2, IL7R/IL7RA, IL9R, IL21R) β-chain Interleukin receptors (IL3R/IL3RA, IL5R/IL5RA) · GM-CSF gp130 Interleukin receptors (IL6RA, 11/IL11RA, 27/IL27RA) · OSMR · LIFR · CNTFR IL12RB1 Interleukin receptors (IL12R/IL12RB1/IL12RB2, IL23R23) Other other CSF receptors (EPO, G-CSF, Thrombopoietin) hormone receptor: GH · prolactin
Type II	Interleukin receptors (IL10R/IL10RA/IL10RB/IL22R/IL22RA2, IL20R/IL20RA/IL20RB, IL28R) · Interferon receptors (-α/β/IFNAR1/IFNAR2, -γ/IFNGR1/IFNGR2)

Ig superfamily

CSF1 · KIT · IL1 (IL1R1, IL1R2) · IL18R/IL18R1

IL-17 family

IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)

S/T

TGF-beta (TGFBR1, TGFBR2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)