Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5, also known as MFI2, is a human gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

section_title =
summary_text = The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.cite web | title = Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Suryo Rahmanto Y, Dunn LL, Richardson DR |title=The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis. |journal=Oncogene |volume=26 |issue= 42 |pages= 6113–24 |year= 2007 |pmid= 17452986 |doi= 10.1038/sj.onc.1210442
*cite journal | author=Baker EN, Baker HM, Smith CA, "et al." |title=Human melanotransferrin (p97) has only one functional iron-binding site. |journal=FEBS Lett. |volume=298 |issue= 2-3 |pages= 215–8 |year= 1992 |pmid= 1544447 |doi=
*cite journal | author=Garratt RC, Jhotí H |title=A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function. |journal=FEBS Lett. |volume=305 |issue= 1 |pages= 55–61 |year= 1992 |pmid= 1633859 |doi=
*cite journal | author=Rose TM, Plowman GD, Teplow DB, "et al." |title=Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 5 |pages= 1261–5 |year= 1986 |pmid= 2419904 |doi=
*cite journal | author=Furukawa KS, Furukawa K, Real FX, "et al." |title=A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97. |journal=J. Exp. Med. |volume=169 |issue= 2 |pages= 585–90 |year= 1989 |pmid= 2463331 |doi=
*cite journal | author=Sciot R, de Vos R, van Eyken P, "et al." |title=In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study. |journal=Liver |volume=9 |issue= 2 |pages= 110–9 |year= 1989 |pmid= 2540389 |doi=
*cite journal | author=Seligman PA, Butler CD, Massey EJ, "et al." |title=The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor. |journal=Am. J. Hum. Genet. |volume=38 |issue= 4 |pages= 540–8 |year= 1986 |pmid= 3010712 |doi=
*cite journal | author=Le Beau MM, Diaz MO, Plowman GD, "et al." |title=Chromosomal sublocalization of the human p97 melanoma antigen. |journal=Hum. Genet. |volume=72 |issue= 4 |pages= 294–6 |year= 1986 |pmid= 3754536 |doi=
*cite journal | author=Plowman GD, Brown JP, Enns CA, "et al." |title=Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3. |journal=Nature |volume=303 |issue= 5912 |pages= 70–2 |year= 1983 |pmid= 6843660 |doi=
*cite journal | author=Kennard ML, Richardson DR, Gabathuler R, "et al." |title=A novel iron uptake mechanism mediated by GPI-anchored human p97. |journal=EMBO J. |volume=14 |issue= 17 |pages= 4178–86 |year= 1995 |pmid= 7556058 |doi=
*cite journal | author=Food MR, Rothenberger S, Gabathuler R, "et al." |title=Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 3034–40 |year= 1994 |pmid= 8300636 |doi=
*cite journal | author=Rothenberger S, Food MR, Gabathuler R, "et al." |title=Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium. |journal=Brain Res. |volume=712 |issue= 1 |pages= 117–21 |year= 1996 |pmid= 8705293 |doi=
*cite journal | author=Chi DD, Merchant RE, Rand R, "et al." |title=Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas. |journal=Am. J. Pathol. |volume=150 |issue= 6 |pages= 2143–52 |year= 1997 |pmid= 9176405 |doi=
*cite journal | author=Richardson DR |title=The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell. |journal=Eur. J. Biochem. |volume=267 |issue= 5 |pages= 1290–8 |year= 2000 |pmid= 10691965 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Suzuki Y, Tsunoda T, Sese J, "et al." |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001
*cite journal | author=Sekyere E, Food MR, Richardson DR |title=A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin? |journal=FEBS Lett. |volume=512 |issue= 1-3 |pages= 350–2 |year= 2002 |pmid= 11852110 |doi=
*cite journal | author=Food MR, Sekyere EO, Richardson DR |title=The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein. |journal=Eur. J. Biochem. |volume=269 |issue= 18 |pages= 4435–45 |year= 2002 |pmid= 12230555 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Guo J, Wen DR, Huang RR, "et al." |title=Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR. |journal=Exp. Mol. Pathol. |volume=74 |issue= 2 |pages= 140–7 |year= 2003 |pmid= 12710945 |doi=

External links


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  • Melanotransferrin — Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 Identifiers Symbols MFI2; CD228; FLJ38863; MAP97; MGC4856; MTF1 External IDs …   Wikipedia

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