Melanotransferrin

Antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
Identifiers
Symbols	MFI2; CD228; FLJ38863; MAP97; MGC4856; MTF1
External IDs	OMIM: 155750 MGI: 1353421 HomoloGene: 4335 GeneCards: MFI2 Gene
Gene Ontology Molecular function • iron ion binding • protein binding • ferric iron binding • metal ion binding Cellular component • extracellular region • plasma membrane • integral to plasma membrane • anchored to membrane Biological process • ion transport • iron ion transport • cellular iron ion homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4241	30060
Ensembl	ENSG00000163975	ENSMUSG00000022780
UniProt	P08582	Q544J8
RefSeq (mRNA)	NM_005929.5	NM_013900.2
RefSeq (protein)	NP_005920.2	NP_038928.1
Location (UCSC)	Chr 3: 196.72 – 196.76 Mb	Chr 16: 31.88 – 31.9 Mb
PubMed search	[1]	[2]

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.^[1]

References

1. ^ "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4241. 

Further reading

• Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis.". Oncogene 26 (42): 6113–24. doi:10.1038/sj.onc.1210442. PMID 17452986. 
• Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site.". FEBS Lett. 298 (2-3): 215–8. doi:10.1016/0014-5793(92)80060-T. PMID 1544447. 
• Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.". FEBS Lett. 305 (1): 55–61. doi:10.1016/0014-5793(92)80654-Y. PMID 1633859. 
• Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.". Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. doi:10.1073/pnas.83.5.1261. PMC 323055. PMID 2419904. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=323055. 
• Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.". J. Exp. Med. 169 (2): 585–90. doi:10.1084/jem.169.2.585. PMC 2189208. PMID 2463331. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2189208. 
• Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study.". Liver 9 (2): 110–9. PMID 2540389. 
• Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor.". Am. J. Hum. Genet. 38 (4): 540–8. PMC 1684788. PMID 3010712. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1684788. 
• Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen.". Hum. Genet. 72 (4): 294–6. doi:10.1007/BF00290951. PMID 3754536. 
• Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3.". Nature 303 (5912): 70–2. doi:10.1038/303070a0. PMID 6843660. 
• Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97.". EMBO J. 14 (17): 4178–86. PMC 394500. PMID 7556058. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=394500. 
• Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.". J. Biol. Chem. 269 (4): 3034–40. PMID 8300636. 
• Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium.". Brain Res. 712 (1): 117–21. doi:10.1016/0006-8993(96)88505-2. PMID 8705293. 
• Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.". Am. J. Pathol. 150 (6): 2143–52. PMC 1858329. PMID 9176405. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1858329. 
• Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID 10691965. 
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267. 
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311086. 
• Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1-3): 350–2. doi:10.1016/S0014-5793(02)02248-2. PMID 11852110. 
• Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.". Eur. J. Biochem. 269 (18): 4435–45. doi:10.1046/j.1432-1033.2002.03140.x. PMID 12230555. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR.". Exp. Mol. Pathol. 74 (2): 140–7. doi:10.1016/S0014-4800(03)00012-1. PMID 12710945. 

External links

• MeSH MFI2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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