- CD133
protein
Name=prominin 1
caption=
width=
HGNCid=9454
Symbol=PROM1
AltSymbols=PROML1, CD133
EntrezGene=8842
OMIM=604365
RefSeq=NM_006017
UniProt=O43490
PDB=
ECnumber=
Chromosome=4
Arm=p
Band=15
LocusSupplementaryData=CD133 is a
glycoprotein also known in humans and rodents as Prominin 1 (PROM1). [cite journal |author=Corbeil D, Fargeas C, Huttner W |title=Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein |journal=Biochem Biophys Res Commun |volume=285 |issue=4 |pages=939–44 |year=2001 |pmid=11467842 |doi=10.1006/bbrc.2001.5271] It is the founding member of pentaspantransmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localizes to cellular protrusions. CD133 is expressed inhematopoietic stem cells ,endothelial progenitor cell s,glioblastoma s,neuron al and glialstem cell s and some other cell types. [cite journal |author=Corbeil D, Röper K, Hellwig A, Tavian M, Miraglia S, Watt S, Simmons P, Peault B, Buck D, Huttner W |title=The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions |journal=J Biol Chem |volume=275 |issue=8 |pages=5512–20 |year=2000 |pmid=10681530 |doi=10.1074/jbc.275.8.5512] [cite journal |author=Shmelkov S, St Clair R, Lyden D, Rafii S |title=AC133/CD133/Prominin-1 |journal=Int J Biochem Cell Biol |volume=37 |issue=4 |pages=715–9 |year=2005 |pmid=15694831 |doi=10.1016/j.biocel.2004.08.010]References
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