Syndecan 1

Syndecan 1

Syndecan 1 is a proteoglycan.

PBB_Summary
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summary_text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [cite web | title = Entrez Gene: SDC1 syndecan 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6382| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=David G |title=Structural and functional diversity of the heparan sulfate proteoglycans. |journal=Adv. Exp. Med. Biol. |volume=313 |issue= |pages= 69–78 |year= 1992 |pmid= 1442271 |doi=
*cite journal | author=Jaakkola P, Jalkanen M |title=Transcriptional regulation of Syndecan-1 expression by growth factors. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=63 |issue= |pages= 109–38 |year= 1999 |pmid= 10506830 |doi=
*cite journal | author=Wijdenes J, Dore JM, Clement C, Vermot-Desroches C |title=CD138. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 152–5 |year= 2003 |pmid= 12144130 |doi=
*cite journal | author=Lories V, Cassiman JJ, Van den Berghe H, David G |title=Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 1116–22 |year= 1992 |pmid= 1339431 |doi=
*cite journal | author=Vainio S, Jalkanen M, Bernfield M, Saxén L |title=Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney. |journal=Dev. Biol. |volume=152 |issue= 2 |pages= 221–32 |year= 1992 |pmid= 1644217 |doi=
*cite journal | author=Kiefer MC, Ishihara M, Swiedler SJ, "et al." |title=The molecular biology of heparan sulfate fibroblast growth factor receptors. |journal=Ann. N. Y. Acad. Sci. |volume=638 |issue= |pages= 167–76 |year= 1992 |pmid= 1664683 |doi=
*cite journal | author=Ala-Kapee M, Nevanlinna H, Mali M, "et al." |title=Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2. |journal=Somat. Cell Mol. Genet. |volume=16 |issue= 5 |pages= 501–5 |year= 1990 |pmid= 2173154 |doi=
*cite journal | author=Mali M, Jaakkola P, Arvilommi AM, Jalkanen M |title=Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. |journal=J. Biol. Chem. |volume=265 |issue= 12 |pages= 6884–9 |year= 1990 |pmid= 2324102 |doi=
*cite journal | author=Sanderson RD, Lalor P, Bernfield M |title=B lymphocytes express and lose syndecan at specific stages of differentiation. |journal=Cell Regul. |volume=1 |issue= 1 |pages= 27–35 |year= 1992 |pmid= 2519615 |doi=
*cite journal | author=Asundi VK, Carey DJ |title=Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26404–10 |year= 1995 |pmid= 7592855 |doi=
*cite journal | author=Zhang L, David G, Esko JD |title=Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27127–35 |year= 1995 |pmid= 7592967 |doi=
*cite journal | author=Barillari G, Gendelman R, Gallo RC, Ensoli B |title=The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 17 |pages= 7941–5 |year= 1993 |pmid= 7690138 |doi=
*cite journal | author=Spring J, Goldberger OA, Jenkins NA, "et al." |title=Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. |journal=Genomics |volume=21 |issue= 3 |pages= 597–601 |year= 1994 |pmid= 7959737 |doi= 10.1006/geno.1994.1319
*cite journal | author=Sneed TB, Stanley DJ, Young LA, Sanderson RD |title=Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells. |journal=Cell. Immunol. |volume=153 |issue= 2 |pages= 456–67 |year= 1994 |pmid= 8118875 |doi= 10.1006/cimm.1994.1042
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kokenyesi R, Bernfield M |title=Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12304–9 |year= 1994 |pmid= 8163535 |doi=
*cite journal | author=Albini A, Benelli R, Presta M, "et al." |title=HIV-tat protein is a heparin-binding angiogenic growth factor. |journal=Oncogene |volume=12 |issue= 2 |pages= 289–97 |year= 1996 |pmid= 8570206 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A |title=The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p. |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 295–7 |year= 1997 |pmid= 9050911 |doi=

External links

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