Syndecan 1

Syndecan 1

Syndecan 1 is a proteoglycan.

section_title =
summary_text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [cite web | title = Entrez Gene: SDC1 syndecan 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=David G |title=Structural and functional diversity of the heparan sulfate proteoglycans. |journal=Adv. Exp. Med. Biol. |volume=313 |issue= |pages= 69–78 |year= 1992 |pmid= 1442271 |doi=
*cite journal | author=Jaakkola P, Jalkanen M |title=Transcriptional regulation of Syndecan-1 expression by growth factors. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=63 |issue= |pages= 109–38 |year= 1999 |pmid= 10506830 |doi=
*cite journal | author=Wijdenes J, Dore JM, Clement C, Vermot-Desroches C |title=CD138. |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 152–5 |year= 2003 |pmid= 12144130 |doi=
*cite journal | author=Lories V, Cassiman JJ, Van den Berghe H, David G |title=Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 1116–22 |year= 1992 |pmid= 1339431 |doi=
*cite journal | author=Vainio S, Jalkanen M, Bernfield M, Saxén L |title=Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney. |journal=Dev. Biol. |volume=152 |issue= 2 |pages= 221–32 |year= 1992 |pmid= 1644217 |doi=
*cite journal | author=Kiefer MC, Ishihara M, Swiedler SJ, "et al." |title=The molecular biology of heparan sulfate fibroblast growth factor receptors. |journal=Ann. N. Y. Acad. Sci. |volume=638 |issue= |pages= 167–76 |year= 1992 |pmid= 1664683 |doi=
*cite journal | author=Ala-Kapee M, Nevanlinna H, Mali M, "et al." |title=Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2. |journal=Somat. Cell Mol. Genet. |volume=16 |issue= 5 |pages= 501–5 |year= 1990 |pmid= 2173154 |doi=
*cite journal | author=Mali M, Jaakkola P, Arvilommi AM, Jalkanen M |title=Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans. |journal=J. Biol. Chem. |volume=265 |issue= 12 |pages= 6884–9 |year= 1990 |pmid= 2324102 |doi=
*cite journal | author=Sanderson RD, Lalor P, Bernfield M |title=B lymphocytes express and lose syndecan at specific stages of differentiation. |journal=Cell Regul. |volume=1 |issue= 1 |pages= 27–35 |year= 1992 |pmid= 2519615 |doi=
*cite journal | author=Asundi VK, Carey DJ |title=Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26404–10 |year= 1995 |pmid= 7592855 |doi=
*cite journal | author=Zhang L, David G, Esko JD |title=Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 27127–35 |year= 1995 |pmid= 7592967 |doi=
*cite journal | author=Barillari G, Gendelman R, Gallo RC, Ensoli B |title=The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 17 |pages= 7941–5 |year= 1993 |pmid= 7690138 |doi=
*cite journal | author=Spring J, Goldberger OA, Jenkins NA, "et al." |title=Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. |journal=Genomics |volume=21 |issue= 3 |pages= 597–601 |year= 1994 |pmid= 7959737 |doi= 10.1006/geno.1994.1319
*cite journal | author=Sneed TB, Stanley DJ, Young LA, Sanderson RD |title=Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells. |journal=Cell. Immunol. |volume=153 |issue= 2 |pages= 456–67 |year= 1994 |pmid= 8118875 |doi= 10.1006/cimm.1994.1042
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Kokenyesi R, Bernfield M |title=Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12304–9 |year= 1994 |pmid= 8163535 |doi=
*cite journal | author=Albini A, Benelli R, Presta M, "et al." |title=HIV-tat protein is a heparin-binding angiogenic growth factor. |journal=Oncogene |volume=12 |issue= 2 |pages= 289–97 |year= 1996 |pmid= 8570206 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A |title=The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p. |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 295–7 |year= 1997 |pmid= 9050911 |doi=

External links


update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Syndecan — One of a family of core proteins with sugars attached to the cell surfaces that control or influence tissue repair, metabolism, the formation of tumors and the development of immune responses. The name is derived from the Greek syndein, to bind… …   Medical dictionary

  • syndecan — An integral membrane proteoglycan (250 300 kD) associated largely with epithelial cells. The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular… …   Dictionary of molecular biology

  • syndecan — noun Any of a class of single transmembrane domain proteins thought to act as coreceptors, especially for G protein coupled receptors …   Wiktionary

  • SDC3 — Syndecan 3, also known as SDC3, is a human gene.cite web | title = Entrez Gene: SDC3 syndecan 3| url = Cmd=ShowDetailView TermToSearch=9672| accessdate = ] PBB Summary section title = summary text …   Wikipedia

  • SDC2 — Syndecan 2, also known as SDC2, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The… …   Wikipedia

  • SDC4 — Syndecan 4, also known as SDC4, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The… …   Wikipedia

  • SDCBP — Syndecan binding protein (syntenin), also known as SDCBP, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene was initially identified as a molecule linking syndecan mediated signaling to the cytoskeleton …   Wikipedia

  • SDCBP2 — Syndecan binding protein (syntenin) 2, also known as SDCBP2, is a human gene.cite web | title = Entrez Gene: SDCBP2 syndecan binding protein (syntenin) 2| url = Cmd=ShowDetailView… …   Wikipedia

  • Sindecán-4 — Este artículo o sección tiene un estilo difícil de entender para lectores que no son expertos en el tema. Si puedes, por favor edítalo y contribuye a hacerlo más accesible para el público general, sin eliminar los detalles técnicos que interesan… …   Wikipedia Español

  • Lacritin — Lacritin, also known as LACRT, is a protein which in humans is encoded by the LACRT gene.cite web | title = Entrez Gene: LACRT lacritin| url = Cmd=ShowDetailView TermToSearch=90070| accessdate = ]… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”