SDCBP

Syndecan binding protein (syntenin), also known as SDCBP, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: SDCBP syndecan binding protein (syntenin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6386| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bass MD, Humphries MJ |title=Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. |journal=Biochem. J. |volume=368 |issue= Pt 1 |pages= 1–15 |year= 2002 |pmid= 12241528 |doi= 10.1042/BJ20021228
*cite journal | author=Harrod TR, Justement LB |title=Evaluating function of transmembrane protein tyrosine phosphatase CD148 in lymphocyte biology. |journal=Immunol. Res. |volume=26 |issue= 1-3 |pages= 153–66 |year= 2003 |pmid= 12403354 |doi=
*cite journal | author=Sarkar D, Boukerche H, Su ZZ, Fisher PB |title=mda-9/syntenin: recent insights into a novel cell signaling and metastasis-associated gene. |journal=Pharmacol. Ther. |volume=104 |issue= 2 |pages= 101–15 |year= 2005 |pmid= 15518882 |doi= 10.1016/j.pharmthera.2004.08.004
*cite journal | author= |title=Letter: The condition of psychiatry. |journal=N. Engl. J. Med. |volume=292 |issue= 18 |pages= 982 |year= 1975 |pmid= 1117941 |doi=
*cite journal | author=Grootjans JJ, Zimmermann P, Reekmans G, "et al." |title=Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13683–8 |year= 1998 |pmid= 9391086 |doi=
*cite journal | author=Lin JJ, Jiang H, Fisher PB |title=Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene. |journal=Gene |volume=207 |issue= 2 |pages= 105–10 |year= 1998 |pmid= 9511750 |doi=
*cite journal | author=Torres R, Firestein BL, Dong H, "et al." |title=PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. |journal=Neuron |volume=21 |issue= 6 |pages= 1453–63 |year= 1999 |pmid= 9883737 |doi=
*cite journal | author=Lin D, Gish GD, Songyang Z, Pawson T |title=The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3726–33 |year= 1999 |pmid= 9920925 |doi=
*cite journal | author=Fernández-Larrea J, Merlos-Suárez A, Ureña JM, "et al." |title=A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 423–33 |year= 1999 |pmid= 10230395 |doi=
*cite journal | author=Fialka I, Steinlein P, Ahorn H, "et al." |title=Identification of syntenin as a protein of the apical early endocytic compartment in Madin-Darby canine kidney cells. |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26233–9 |year= 1999 |pmid= 10473577 |doi=
*cite journal | author=Grootjans JJ, Reekmans G, Ceulemans H, David G |title=Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19933–41 |year= 2000 |pmid= 10770943 |doi= 10.1074/jbc.M002459200
*cite journal | author=Koroll M, Rathjen FG, Volkmer H |title=The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. |journal=J. Biol. Chem. |volume=276 |issue= 14 |pages= 10646–54 |year= 2001 |pmid= 11152476 |doi= 10.1074/jbc.M010647200
*cite journal | author=Zimmermann P, Tomatis D, Rosas M, "et al." |title=Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. |journal=Mol. Biol. Cell |volume=12 |issue= 2 |pages= 339–50 |year= 2001 |pmid= 11179419 |doi=
*cite journal | author=Jannatipour M, Dion P, Khan S, "et al." |title=Schwannomin isoform-1 interacts with syntenin via PDZ domains. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33093–100 |year= 2001 |pmid= 11432873 |doi= 10.1074/jbc.M105792200
*cite journal | author=Geijsen N, Uings IJ, Pals C, "et al." |title=Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. |journal=Science |volume=293 |issue= 5532 |pages= 1136–8 |year= 2001 |pmid= 11498591 |doi= 10.1126/science.1059157
*cite journal | author=Hirbec H, Perestenko O, Nishimune A, "et al." |title=The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15221–4 |year= 2002 |pmid= 11891216 |doi= 10.1074/jbc.C200112200
*cite journal | author=Koo TH, Lee JJ, Kim EM, "et al." |title=Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. |journal=Oncogene |volume=21 |issue= 26 |pages= 4080–8 |year= 2002 |pmid= 12037664 |doi= 10.1038/sj.onc.1205514
*cite journal | author=Biederer T, Sara Y, Mozhayeva M, "et al." |title=SynCAM, a synaptic adhesion molecule that drives synapse assembly. |journal=Science |volume=297 |issue= 5586 |pages= 1525–31 |year= 2002 |pmid= 12202822 |doi= 10.1126/science.1072356

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