SDC2

Syndecan 2, also known as SDC2, is a human gene.

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summary_text = The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.cite web | title = Entrez Gene: SDC2 syndecan 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6383| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mahley RW, Ji ZS |title=Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. |journal=J. Lipid Res. |volume=40 |issue= 1 |pages= 1–16 |year= 1999 |pmid= 9869645 |doi=
*cite journal | author=Labarrere CA, Pitts D, Halbrook H, Faulk WP |title=Natural anticoagulant pathways in normal and transplanted human hearts. |journal=J. Heart Lung Transplant. |volume=11 |issue= 2 Pt 1 |pages= 342–7 |year= 1992 |pmid= 1315572 |doi=
*cite journal | author=Marynen P, Zhang J, Cassiman JJ, "et al." |title=Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. Prediction of an integral membrane domain and evidence for multiple distinct core proteins at the cell surface of human lung fibroblasts. |journal=J. Biol. Chem. |volume=264 |issue= 12 |pages= 7017–24 |year= 1989 |pmid= 2523388 |doi=
*cite journal | author=Sage H, Vernon RB, Funk SE, "et al." |title=SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. |journal=J. Cell Biol. |volume=109 |issue= 1 |pages= 341–56 |year= 1989 |pmid= 2745554 |doi=
*cite journal | author=Lories V, De Boeck H, David G, "et al." |title=Heparan sulfate proteoglycans of human lung fibroblasts. Structural heterogeneity of the core proteins of the hydrophobic cell-associated forms. |journal=J. Biol. Chem. |volume=262 |issue= 2 |pages= 854–9 |year= 1987 |pmid= 2948951 |doi=
*cite journal | author=Brown KJ, Parish CR |title=Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor. |journal=Biochemistry |volume=33 |issue= 46 |pages= 13918–27 |year= 1994 |pmid= 7524669 |doi=
*cite journal | author=Bolton P, Powell J, Rutter M, "et al." |title=Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1). |journal=Psychiatr. Genet. |volume=5 |issue= 2 |pages= 51–5 |year= 1995 |pmid= 7551962 |doi=
*cite journal | author=Barillari G, Gendelman R, Gallo RC, Ensoli B |title=The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 17 |pages= 7941–5 |year= 1993 |pmid= 7690138 |doi=
*cite journal | author=Lyon M, Deakin JA, Mizuno K, "et al." |title=Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11216–23 |year= 1994 |pmid= 8157651 |doi=
*cite journal | author=David G, Bai XM, Van der Schueren B, "et al." |title=Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. |journal=Development |volume=119 |issue= 3 |pages= 841–54 |year= 1994 |pmid= 8187643 |doi=
*cite journal | author=Albini A, Benelli R, Presta M, "et al." |title=HIV-tat protein is a heparin-binding angiogenic growth factor. |journal=Oncogene |volume=12 |issue= 2 |pages= 289–97 |year= 1996 |pmid= 8570206 |doi=
*cite journal | author=Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, "et al." |title=Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system. |journal=J. Cell. Sci. |volume=109 ( Pt 7) |issue= |pages= 1749–57 |year= 1997 |pmid= 8832397 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Christa L, Carnot F, Simon MT, "et al." |title=HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. |journal=Am. J. Physiol. |volume=271 |issue= 6 Pt 1 |pages= G993–1002 |year= 1997 |pmid= 8997243 |doi=
*cite journal | author=Rusnati M, Coltrini D, Oreste P, "et al." |title=Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. |journal=J. Biol. Chem. |volume=272 |issue= 17 |pages= 11313–20 |year= 1997 |pmid= 9111037 |doi=
*cite journal | author=Oh ES, Couchman JR, Woods A |title=Serine phosphorylation of syndecan-2 proteoglycan cytoplasmic domain. |journal=Arch. Biochem. Biophys. |volume=344 |issue= 1 |pages= 67–74 |year= 1997 |pmid= 9244383 |doi= 10.1006/abbi.1997.0180
*cite journal | author=Ishikawa-Brush Y, Powell JF, Bolton P, "et al." |title=Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1241–50 |year= 1997 |pmid= 9259269 |doi=
*cite journal | author=Chang HC, Samaniego F, Nair BC, "et al." |title=HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. |journal=AIDS |volume=11 |issue= 12 |pages= 1421–31 |year= 1997 |pmid= 9342064 |doi=
*cite journal | author=Grootjans JJ, Zimmermann P, Reekmans G, "et al." |title=Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13683–8 |year= 1998 |pmid= 9391086 |doi=
*cite journal | author=Cohen AR, Woods DF, Marfatia SM, "et al." |title=Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. |journal=J. Cell Biol. |volume=142 |issue= 1 |pages= 129–38 |year= 1998 |pmid= 9660868 |doi=

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