LAIR1

LAIR1

Leukocyte-associated immunoglobulin-like receptor 1, also known as LAIR1, is a human gene.cite web | title = Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3903| accessdate = ] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

PBB_Summary
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summary_text = The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.cite web | title = Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3903| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sinclair NR |title=Why so many coinhibitory receptors? |journal=Scand. J. Immunol. |volume=50 |issue= 1 |pages= 10–3 |year= 1999 |pmid= 10404045 |doi=
*cite journal | author=Meyaard L |title=LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells. |journal=Curr. Top. Microbiol. Immunol. |volume=244 |issue= |pages= 151–7 |year= 1999 |pmid= 10453657 |doi=
*cite journal | author=Meyaard L |title=Leukocyte associated Ig-like receptor (LAIR). |journal=J. Biol. Regul. Homeost. Agents |volume=17 |issue= 4 |pages= 330–3 |year= 2004 |pmid= 15065762 |doi=
*cite journal | author=Meyaard L, Adema GJ, Chang C, "et al." |title=LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. |journal=Immunity |volume=7 |issue= 2 |pages= 283–90 |year= 1997 |pmid= 9285412 |doi=
*cite journal | author=Poggi A, Tomasello E, Ferrero E, "et al." |title=p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor. |journal=Eur. J. Immunol. |volume=28 |issue= 7 |pages= 2086–91 |year= 1998 |pmid= 9692876 |doi=
*cite journal | author=Meyaard L, Hurenkamp J, Clevers H, "et al." |title=Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. |journal=J. Immunol. |volume=162 |issue= 10 |pages= 5800–4 |year= 1999 |pmid= 10229813 |doi=
*cite journal | author=van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L |title=Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3160–7 |year= 1999 |pmid= 10540327 |doi=
*cite journal | author=Xu M, Zhao R, Zhao ZJ |title=Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17440–6 |year= 2000 |pmid= 10764762 |doi= 10.1074/jbc.M001313200
*cite journal | author=Poggi A, Pellegatta F, Leone BE, "et al." |title=Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. |journal=Eur. J. Immunol. |volume=30 |issue= 10 |pages= 2751–8 |year= 2000 |pmid= 11069054 |doi=
*cite journal | author=Sathish JG, Johnson KG, Fuller KJ, "et al." |title=Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. |journal=J. Immunol. |volume=166 |issue= 3 |pages= 1763–70 |year= 2001 |pmid= 11160222 |doi=
*cite journal | author=Meyaard L, van der Vuurst de Vries AR, de Ruiter T, "et al." |title=The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). |journal=J. Exp. Med. |volume=194 |issue= 1 |pages= 107–12 |year= 2001 |pmid= 11435477 |doi=
*cite journal | author=Saverino D, Fabbi M, Merlo A, "et al." |title=Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions. |journal=Hum. Immunol. |volume=63 |issue= 7 |pages= 534–46 |year= 2002 |pmid= 12072189 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Aoukaty A, Lee IF, Wu J, Tan R |title=Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells. |journal=J. Clin. Immunol. |volume=23 |issue= 2 |pages= 141–5 |year= 2004 |pmid= 12757266 |doi=
*cite journal | author=Verbrugge A, Ruiter Td T, Clevers H, Meyaard L |title=Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. |journal=Int. Immunol. |volume=15 |issue= 11 |pages= 1349–58 |year= 2004 |pmid= 14565933 |doi=
*cite journal | author=De Milito A, Nilsson A, Titanji K, "et al." |title=Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection. |journal=Blood |volume=103 |issue= 6 |pages= 2180–6 |year= 2004 |pmid= 14604962 |doi= 10.1182/blood-2003-07-2375
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

External links

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