- LRP1
Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), also known as LRP1 or CD91, is a
protein forming a receptor found in theplasma membrane of human cells involved in receptor-mediatedendocytosis .LRP1 and Alzheimer's disease
Neuron s requirecholesterol to function. Cholesterol is imported into the neuron by the apolipoproteinapoE4 via LRP1 receptors on the cell surface. It thought that a causal factor inAlzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol. [Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. PMID 17920016]PBB_Summary
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ee also
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Cluster of differentiation
*Low density lipoprotein receptor gene family Further reading
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*cite journal | author=Li Z, Dai J, Zheng H, "et al." |title=An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. |journal=Front. Biosci. |volume=7 |issue= |pages= d731–51 |year= 2002 |pmid= 11861214 |doi=
*cite journal | author=van der Geer P |title=Phosphorylation of LRP1: regulation of transport and signal transduction. |journal=Trends Cardiovasc. Med. |volume=12 |issue= 4 |pages= 160–5 |year= 2002 |pmid= 12069755 |doi=
*cite journal | author=May P, Herz J |title=LDL receptor-related proteins in neurodevelopment. |journal=Traffic |volume=4 |issue= 5 |pages= 291–301 |year= 2004 |pmid= 12713657 |doi=
*cite journal | author=Llorente-Cortés V, Badimon L |title=LDL receptor-related protein and the vascular wall: implications for atherothrombosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 3 |pages= 497–504 |year= 2005 |pmid= 15705932 |doi= 10.1161/01.ATV.0000154280.62072.fd
*cite journal | author=Huang SS, Huang JS |title=TGF-beta control of cell proliferation. |journal=J. Cell. Biochem. |volume=96 |issue= 3 |pages= 447–62 |year= 2005 |pmid= 16088940 |doi= 10.1002/jcb.20558
*cite journal | author=Lillis AP, Mikhailenko I, Strickland DK |title=Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1884–93 |year= 2005 |pmid= 16102056 |doi= 10.1111/j.1538-7836.2005.01371.xExternal links
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