CD1D

CD1D

CD1d is a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules.

CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

Nomenclature

*CD1d is also known as R3G1

Further reading

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citations =
*cite journal | author=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82–8 |year= 1996 |pmid= 8729450 |doi=
*cite journal | author=Joyce S |title=CD1d and natural T cells: how their properties jump-start the immune system. |journal=Cell. Mol. Life Sci. |volume=58 |issue= 3 |pages= 442–69 |year= 2001 |pmid= 11315191 |doi=
*cite journal | author=Sköld M, Behar SM |title=Role of CD1d-restricted NKT cells in microbial immunity. |journal=Infect. Immun. |volume=71 |issue= 10 |pages= 5447–55 |year= 2003 |pmid= 14500461 |doi=
*cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817–90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608
*cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=
*cite journal | author=Brutkiewicz RR |title=CD1d ligands: the good, the bad, and the ugly. |journal=J. Immunol. |volume=177 |issue= 2 |pages= 769–75 |year= 2006 |pmid= 16818729 |doi=
*cite journal | author=Blumberg RS, Terhorst C, Bleicher P, "et al." |title=Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells. |journal=J. Immunol. |volume=147 |issue= 8 |pages= 2518–24 |year= 1991 |pmid= 1717564 |doi=
*cite journal | author=Balk SP, Bleicher PA, Terhorst C |title=Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 252–6 |year= 1989 |pmid= 2463622 |doi=
*cite journal | author=Calabi F, Jarvis JM, Martin L, Milstein C |title=Two classes of CD1 genes. |journal=Eur. J. Immunol. |volume=19 |issue= 2 |pages= 285–92 |year= 1989 |pmid= 2467814 |doi=
*cite journal | author=Yu CY, Milstein C |title=A physical map linking the five CD1 human thymocyte differentiation antigen genes. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3727–32 |year= 1990 |pmid= 2583117 |doi=
*cite journal | author=Martin LH, Calabi F, Milstein C |title=Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9154–8 |year= 1987 |pmid= 3097645 |doi=
*cite journal | author=Balk SP, Burke S, Polischuk JE, "et al." |title=Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. |journal=Science |volume=265 |issue= 5169 |pages= 259–62 |year= 1994 |pmid= 7517575 |doi=
*cite journal |author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kawano T, Cui J, Koezuka Y, "et al." |title=CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. |journal=Science |volume=278 |issue= 5343 |pages= 1626–9 |year= 1997 |pmid= 9374463 |doi=
*cite journal | author=Katabami S, Matsuura A, Chen HZ, "et al." |title=Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes. |journal=Immunogenetics |volume=48 |issue= 1 |pages= 22–31 |year= 1998 |pmid= 9601940 |doi=
*cite journal | author=Somnay-Wadgaonkar K, Nusrat A, Kim HS, "et al." |title=Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form. |journal=Int. Immunol. |volume=11 |issue= 3 |pages= 383–92 |year= 1999 |pmid= 10221650 |doi=
*cite journal | author=Campbell NA, Kim HS, Blumberg RS, Mayer L |title=The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells. |journal=J. Biol. Chem. |volume=274 |issue= 37 |pages= 26259–65 |year= 1999 |pmid= 10473580 |doi=
*cite journal | author=Han M, Hannick LI, DiBrino M, Robinson MA |title=Polymorphism of human CD1 genes. |journal=Tissue Antigens |volume=54 |issue= 2 |pages= 122–7 |year= 2000 |pmid= 10488738 |doi=

External links

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