KIR2DL1

KIR2DL1

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1, also known as KIR2DL1, is a human gene.cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = ]

PBB_Summary
section_title =
summary_text = Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.cite web | title = Entrez Gene: KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3802| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Colonna M, Samaridis J |title=Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. |journal=Science |volume=268 |issue= 5209 |pages= 405–8 |year= 1995 |pmid= 7716543 |doi=
*cite journal | author=Wagtmann N, Biassoni R, Cantoni C, "et al." |title=Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. |journal=Immunity |volume=2 |issue= 5 |pages= 439–49 |year= 1995 |pmid= 7749980 |doi=
*cite journal | author=Fan QR, Mosyak L, Winter CC, "et al." |title=Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors. |journal=Nature |volume=389 |issue= 6646 |pages= 96–100 |year= 1997 |pmid= 9288975 |doi= 10.1038/38028
*cite journal | author=Kim J, Chwae YJ, Kim MY, "et al." |title=Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 3875–82 |year= 1997 |pmid= 9378975 |doi=
*cite journal | author=Valiante NM, Uhrberg M, Shilling HG, "et al." |title=Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. |journal=Immunity |volume=7 |issue= 6 |pages= 739–51 |year= 1998 |pmid= 9430220 |doi=
*cite journal | author=Uhrberg M, Valiante NM, Shum BP, "et al." |title=Human diversity in killer cell inhibitory receptor genes. |journal=Immunity |volume=7 |issue= 6 |pages= 753–63 |year= 1998 |pmid= 9430221 |doi=
*cite journal | author=Rajagopalan S, Long EO |title=Zinc bound to the killer cell-inhibitory receptor modulates the negative signal in human NK cells. |journal=J. Immunol. |volume=161 |issue= 3 |pages= 1299–305 |year= 1998 |pmid= 9686591 |doi=
*cite journal | author=Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL |title=Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors. |journal=Immunity |volume=9 |issue= 3 |pages= 337–44 |year= 1998 |pmid= 9768753 |doi=
*cite journal | author=Shilling HG, Lienert-Weidenbach K, Valiante NM, "et al." |title=Evidence for recombination as a mechanism for KIR diversification. |journal=Immunogenetics |volume=48 |issue= 6 |pages= 413–6 |year= 1998 |pmid= 9799338 |doi=
*cite journal | author=Chwae YJ, Cho SE, Kim SJ, Kim J |title=Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual. |journal=Immunol. Lett. |volume=68 |issue= 2-3 |pages= 267–74 |year= 1999 |pmid= 10424431 |doi=
*cite journal | author=Fan QR, Wiley DC |title=Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor. |journal=J. Exp. Med. |volume=190 |issue= 1 |pages= 113–23 |year= 1999 |pmid= 10429675 |doi=
*cite journal | author=Richardson J, Reyburn HT, Luque I, "et al." |title=Definition of polymorphic residues on killer Ig-like receptor proteins which contribute to the HLA-C binding site. |journal=Eur. J. Immunol. |volume=30 |issue= 5 |pages= 1480–5 |year= 2000 |pmid= 10820396 |doi=
*cite journal | author=Fan QR, Long EO, Wiley DC |title=A disulfide-linked natural killer cell receptor dimer has higher affinity for HLA-C than wild-type monomer. |journal=Eur. J. Immunol. |volume=30 |issue= 9 |pages= 2692–7 |year= 2000 |pmid= 11009104 |doi= 10.1002/1521-4141(200009)30:9<2692::AID-IMMU2692>3.0.CO;2-0 |doilabel=10.1002/1521-4141(200009)30:92692::AID-IMMU26923.0.CO;2-0
*cite journal | author=Baba E, Erskine R, Boyson JE, "et al." |title=N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors. |journal=Hum. Immunol. |volume=61 |issue= 12 |pages= 1202–18 |year= 2001 |pmid= 11163076 |doi=
*cite journal | author=Rajalingam R, Gardiner CM, Canavez F, "et al." |title=Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. |journal=Tissue Antigens |volume=57 |issue= 1 |pages= 22–31 |year= 2001 |pmid= 11169255 |doi=
*cite journal | author=Fan QR, Long EO, Wiley DC |title=Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. |journal=Nat. Immunol. |volume=2 |issue= 5 |pages= 452–60 |year= 2001 |pmid= 11323700 |doi= 10.1038/87766
*cite journal | author=Guerra N, Michel F, Gati A, "et al." |title=Engagement of the inhibitory receptor CD158a interrupts TCR signaling, preventing dynamic membrane reorganization in CTL/tumor cell interaction. |journal=Blood |volume=100 |issue= 8 |pages= 2874–81 |year= 2002 |pmid= 12351398 |doi= 10.1182/blood-2002-02-0643
*cite journal | author=Spaggiari GM, Contini P, Dondero A, "et al." |title=Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. |journal=Blood |volume=100 |issue= 12 |pages= 4098–107 |year= 2003 |pmid= 12393468 |doi= 10.1182/blood-2002-04-1284
*cite journal | author=Boyson JE, Erskine R, Whitman MC, "et al." |title=Disulfide bond-mediated dimerization of HLA-G on the cell surface. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 25 |pages= 16180–5 |year= 2003 |pmid= 12454284 |doi= 10.1073/pnas.212643199
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • HLA-C — Major histocompatibility complex, class I, C Illustation of an HLA C showing the HLA B alpha chain, ?2 Microglobulin, and the end of a peptide bound in the binding cleft …   Wikipedia

  • Immune system — A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and… …   Wikipedia

  • Major histocompatibility complex — The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates that encodes MHC molecules. MHC molecules play an important role in the immune system and autoimmunity. Proteins are continually… …   Wikipedia

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

  • CD4 — For other uses, see CD 4 (disambiguation). CD4 molecule Crystallographic structure of the V set and C2 domains of human CD4.[1] …   Wikipedia

  • MHC class I — Schematic representation of MHC class I MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other one being MHC class II) and are found on every nucleated cell of the body (and thus not on …   Wikipedia

  • Cyclophilin — peptidylprolyl isomerase A (cyclophilin A) Ribbon diagram of cyclophilin A in complex with ciclosporin (yellow). From PDB 1CWA …   Wikipedia

  • Complement receptor 2 — Complement component (3d/Epstein Barr virus) receptor 2 PDB rendering based on 1ghq …   Wikipedia

  • MHC class II — Schematic representation of MHC class II MHC (major histocompatibility complex) Class II molecules are found only on a few specialized cell types, including macrophages, dendritic cells and B cells, all of which are professional antigen… …   Wikipedia

  • Neonatal Fc receptor — Fc fragment of IgG, receptor, transporter, alpha Identifiers Symbol FCGRT Entrez 2217 HUGO …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”