TNFRSF10B

Tumor necrosis factor receptor superfamily, member 10b, also known as TNFRSF10B, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [cite web | title = Entrez Gene: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8795| accessdate = ]

ee also

* Cluster of differentiation
* Tumor necrosis factor receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Abe K, Kurakin A, Mohseni-Maybodi M, "et al." |title=The complexity of TNF-related apoptosis-inducing ligand. |journal=Ann. N. Y. Acad. Sci. |volume=926 |issue= |pages= 52–63 |year= 2001 |pmid= 11193041 |doi=
*cite journal | author=Cha SS, Song YL, Oh BH |title=Specificity of molecular recognition learned from the crystal structures of TRAIL and the TRAIL:sDR5 complex. |journal=Vitam. Horm. |volume=67 |issue= |pages= 1–17 |year= 2004 |pmid= 15110168 |doi= 10.1016/S0083-6729(04)67001-4
*cite journal | author=Kimberley FC, Screaton GR |title=Following a TRAIL: update on a ligand and its five receptors. |journal=Cell Res. |volume=14 |issue= 5 |pages= 359–72 |year= 2005 |pmid= 15538968 |doi= 10.1038/sj.cr.7290236
*cite journal | author=Pan G, Ni J, Wei YF, "et al." |title=An antagonist decoy receptor and a death domain-containing receptor for TRAIL. |journal=Science |volume=277 |issue= 5327 |pages= 815–8 |year= 1997 |pmid= 9242610 |doi=
*cite journal | author=Sheridan JP, Marsters SA, Pitti RM, "et al." |title=Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. |journal=Science |volume=277 |issue= 5327 |pages= 818–21 |year= 1997 |pmid= 9242611 |doi=
*cite journal | author=Screaton GR, Mongkolsapaya J, Xu XN, "et al." |title=TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. |journal=Curr. Biol. |volume=7 |issue= 9 |pages= 693–6 |year= 1998 |pmid= 9285725 |doi=
*cite journal | author=Walczak H, Degli-Esposti MA, Johnson RS, "et al." |title=TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5386–97 |year= 1997 |pmid= 9311998 |doi= 10.1093/emboj/16.17.5386
*cite journal | author=MacFarlane M, Ahmad M, Srinivasula SM, "et al." |title=Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25417–20 |year= 1997 |pmid= 9325248 |doi=
*cite journal | author=Wu GS, Burns TF, McDonald ER, "et al." |title=KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. |journal=Nat. Genet. |volume=17 |issue= 2 |pages= 141–3 |year= 1997 |pmid= 9326928 |doi= 10.1038/ng1097-141
*cite journal | author=Schneider P, Bodmer JL, Thome M, "et al." |title=Characterization of two receptors for TRAIL. |journal=FEBS Lett. |volume=416 |issue= 3 |pages= 329–34 |year= 1997 |pmid= 9373179 |doi=
*cite journal | author=Marsters SA, Sheridan JP, Pitti RM, "et al." |title=A novel receptor for Apo2L/TRAIL contains a truncated death domain. |journal=Curr. Biol. |volume=7 |issue= 12 |pages= 1003–6 |year= 1998 |pmid= 9382840 |doi=
*cite journal | author=Chaudhary PM, Eby M, Jasmin A, "et al." |title=Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. |journal=Immunity |volume=7 |issue= 6 |pages= 821–30 |year= 1998 |pmid= 9430227 |doi=
*cite journal | author=Schneider P, Thome M, Burns K, "et al." |title=TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. |journal=Immunity |volume=7 |issue= 6 |pages= 831–6 |year= 1998 |pmid= 9430228 |doi=
*cite journal | author=Pai SI, Wu GS, Ozören N, "et al." |title=Rare loss-of-function mutation of a death receptor gene in head and neck cancer. |journal=Cancer Res. |volume=58 |issue= 16 |pages= 3513–8 |year= 1998 |pmid= 9721851 |doi=
*cite journal | author=Arai T, Akiyama Y, Okabe S, "et al." |title=Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. |journal=Cancer Lett. |volume=133 |issue= 2 |pages= 197–204 |year= 1999 |pmid= 10072170 |doi=
*cite journal | author=Mongkolsapaya J, Grimes JM, Chen N, "et al." |title=Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation. |journal=Nat. Struct. Biol. |volume=6 |issue= 11 |pages= 1048–53 |year= 2002 |pmid= 10542098 |doi= 10.1038/14935
*cite journal | author=Hymowitz SG, Christinger HW, Fuh G, "et al." |title=Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. |journal=Mol. Cell |volume=4 |issue= 4 |pages= 563–71 |year= 1999 |pmid= 10549288 |doi=
*cite journal | author=Kuang AA, Diehl GE, Zhang J, Winoto A |title=FADD is required for DR4- and DR5-mediated apoptosis: lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25065–8 |year= 2000 |pmid= 10862756 |doi= 10.1074/jbc.C000284200
*cite journal | author=Trauzold A, Wermann H, Arlt A, "et al." |title=CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. |journal=Oncogene |volume=20 |issue= 31 |pages= 4258–69 |year= 2001 |pmid= 11464292 |doi= 10.1038/sj.onc.1204559

External links

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