Toll-like receptor 8, also known as TLR8, is a human gene. TLR8 has also been designated as CD288 (cluster of differentiation 288).
Function
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [cite web | title = Entrez Gene: TLR8 toll-like receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51311| accessdate = ]
TLR8 recognises G-rich oligonucleotides.[cite journal | author = Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF | title = Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function | journal = Science (New York, N.Y.) | volume = 309 | issue = 5739 | pages = 1380–4 | year = 2005 | month = August | pmid = 16123302 | doi = 10.1126/science.1113401 | url = | issn = ] ]Clinical significance
Genetics variants in TLR8 has recently been linked to susceptibility to pulmonary tuberculosis.[cite journal | author = Davila S, Hibberd ML, Hari Dass R, Wong HEE, Sahiratmadja E, Bonnard C, Alisjahbana B, Szeszko JS, Balabanova Y, Drobniewski F, van Crevel R, van de Vosse E, Nejentsev S, Ottenhoff THM, Seielstad M | title = Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis | journal = PLoS Genetics | volume = 4 | issue = 10 | pages = e1000218 | year = | month = | pmid = | doi = doi:10.1371/journal.pgen.1000218 | url = | issn = ] ]References
Further reading
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*cite journal | author=Lien E, Ingalls RR |title=Toll-like receptors. |journal=Crit. Care Med. |volume=30 |issue= 1 Suppl |pages= S1–11 |year= 2002 |pmid= 11782555 |doi=
*cite journal | author=Kaisho T, Akira S |title=Toll-like receptors as adjuvant receptors. |journal=Biochim. Biophys. Acta |volume=1589 |issue= 1 |pages= 1–13 |year= 2002 |pmid= 11909637 |doi=
External links
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