CD1A

CD1a (Cluster of Differentiation 1a) is a human protein encoded by the gene|CD1A gene.cite web | title = Entrez Gene: CD1A CD1a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=909| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.cite web | title = Entrez Gene: CD1A CD1a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=909| accessdate = ]

ee also

* CD1

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82–8 |year= 1996 |pmid= 8729450 |doi=
*cite journal | author=Park SH, Bendelac A |title=CD1-restricted T-cell responses and microbial infection. |journal=Nature |volume=406 |issue= 6797 |pages= 788–92 |year= 2000 |pmid= 10963609 |doi= 10.1038/35021233
*cite journal | author=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= |pages= 817–90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608
*cite journal | author=Coventry B, Heinzel S |title=CD1a in human cancers: a new role for an old molecule. |journal=Trends Immunol. |volume=25 |issue= 5 |pages= 242–8 |year= 2004 |pmid= 15099564 |doi= 10.1016/j.it.2004.03.002
*cite journal | author=Moody DB, Zajonc DM, Wilson IA |title=Anatomy of CD1-lipid antigen complexes. |journal=Nat. Rev. Immunol. |volume=5 |issue= 5 |pages= 387–99 |year= 2005 |pmid= 15864273 |doi= 10.1038/nri1605
*cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=
*cite journal | author=Quaranta MG, Mattioli B, Giordani L, Viora M |title=The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. |journal=FASEB J. |volume=20 |issue= 13 |pages= 2198–208 |year= 2006 |pmid= 17077296 |doi= 10.1096/fj.06-6260rev
*cite journal | author=Oakey RJ, Watson ML, Seldin MF |title=Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA. |journal=Hum. Mol. Genet. |volume=1 |issue= 8 |pages= 613–20 |year= 1993 |pmid= 1301170 |doi=
*cite journal | author=Martin LH, Calabi F, Lefebvre FA, "et al." |title=Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 24 |pages= 9189–93 |year= 1988 |pmid= 2447586 |doi=
*cite journal | author=Moseley WS, Watson ML, Kingsmore SF, Seldin MF |title=CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3. |journal=Immunogenetics |volume=30 |issue= 5 |pages= 378–82 |year= 1989 |pmid= 2478463 |doi=
*cite journal | author=Yu CY, Milstein C |title=A physical map linking the five CD1 human thymocyte differentiation antigen genes. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3727–32 |year= 1990 |pmid= 2583117 |doi=
*cite journal | author=Aruffo A, Seed B |title=Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. |journal=J. Immunol. |volume=143 |issue= 5 |pages= 1723–30 |year= 1989 |pmid= 2701945 |doi=
*cite journal | author=Longley J, Kraus J, Alonso M, Edelson R |title=Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. |journal=J. Invest. Dermatol. |volume=92 |issue= 4 |pages= 628–31 |year= 1989 |pmid= 2784820 |doi=
*cite journal | author=Albertson DG, Fishpool R, Sherrington P, "et al." |title=Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. |journal=EMBO J. |volume=7 |issue= 9 |pages= 2801–5 |year= 1988 |pmid= 3053166 |doi=
*cite journal | author=Calabi F, Milstein C |title=A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. |journal=Nature |volume=323 |issue= 6088 |pages= 540–3 |year= 1986 |pmid= 3093894 |doi= 10.1038/323540a0
*cite journal | author=Martin LH, Calabi F, Milstein C |title=Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9154–8 |year= 1987 |pmid= 3097645 |doi=
*cite journal | author=Woolfson A, Milstein C |title=Alternative splicing generates secretory isoforms of human CD1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6683–7 |year= 1994 |pmid= 7517559 |doi=
*cite journal | author=Han M, Hannick LI, DiBrino M, Robinson MA |title=Polymorphism of human CD1 genes. |journal=Tissue Antigens |volume=54 |issue= 2 |pages= 122–7 |year= 2000 |pmid= 10488738 |doi=
*cite journal | author=Sugita M, Grant EP, van Donselaar E, "et al." |title=Separate pathways for antigen presentation by CD1 molecules. |journal=Immunity |volume=11 |issue= 6 |pages= 743–52 |year= 2000 |pmid= 10626896 |doi=

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