CD8A

CD8a (Cluster of Differentiation 8a), is a human gene.cite web | title = Entrez Gene: CD8A CD8a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=925| accessdate = ]

PBB_Summary
section_title =
summary_text = The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified.cite web | title = Entrez Gene: CD8A CD8a molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=925| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Parnes JR |title=Molecular biology and function of CD4 and CD8. |journal=Adv. Immunol. |volume=44 |issue= |pages= 265–311 |year= 1989 |pmid= 2493728 |doi=
*cite journal | author=Li L, Li HS, Pauza CD, "et al." |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370
*cite journal | author=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=
*cite journal | author=Nakayama K, Kawachi Y, Tokito S, "et al." |title=Recent duplication of the two human CD8 beta-chain genes. |journal=J. Immunol. |volume=148 |issue= 6 |pages= 1919–27 |year= 1992 |pmid= 1541829 |doi=
*cite journal | author=Leahy DJ, Axel R, Hendrickson WA |title=Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. |journal=Cell |volume=68 |issue= 6 |pages= 1145–62 |year= 1992 |pmid= 1547508 |doi=
*cite journal | author=Erickson JD, Trojanowski JQ, Eiden LE |title=Regional distribution and partial molecular characterization of CD4-related mRNA in human brain and peripheral tissues. |journal=Brain Res. Mol. Brain Res. |volume=10 |issue= 1 |pages= 23–31 |year= 1991 |pmid= 1676132 |doi=
*cite journal | author=Moebius U, Kober G, Griscelli AL, "et al." |title=Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. |journal=Eur. J. Immunol. |volume=21 |issue= 8 |pages= 1793–800 |year= 1991 |pmid= 1831127 |doi=
*cite journal | author=Mittler RS, Rankin BM, Kiener PA |title=Physical associations between CD45 and CD4 or CD8 occur as late activation events in antigen receptor-stimulated human T cells. |journal=J. Immunol. |volume=147 |issue= 10 |pages= 3434–40 |year= 1991 |pmid= 1834739 |doi=
*cite journal | author=Sanders SK, Giblin PA, Kavathas P |title=Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts. |journal=J. Exp. Med. |volume=174 |issue= 3 |pages= 737–40 |year= 1991 |pmid= 1908512 |doi=
*cite journal | author=Barber EK, Dasgupta JD, Schlossman SF, "et al." |title=The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 9 |pages= 3277–81 |year= 1989 |pmid= 2470098 |doi=
*cite journal | author=Norment AM, Lonberg N, Lacy E, Littman DR |title=Alternatively spliced mRNA encodes a secreted form of human CD8 alpha. Characterization of the human CD8 alpha gene. |journal=J. Immunol. |volume=142 |issue= 9 |pages= 3312–9 |year= 1989 |pmid= 2496167 |doi=
*cite journal | author=Nakayama K, Tokito S, Okumura K, Nakauchi H |title=Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8). |journal=Immunogenetics |volume=30 |issue= 5 |pages= 393–7 |year= 1989 |pmid= 2509342 |doi=
*cite journal | author=Giblin P, Ledbetter JA, Kavathas P |title=A secreted form of the human lymphocyte cell surface molecule CD8 arises from alternative splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 3 |pages= 998–1002 |year= 1989 |pmid= 2536941 |doi=
*cite journal | author=Aruffo A, Seed B |title=Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. |journal=J. Immunol. |volume=143 |issue= 5 |pages= 1723–30 |year= 1989 |pmid= 2701945 |doi=
*cite journal | author=Bowcock AM, Kavathas P, Margolskee RF, "et al." |title=An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12. |journal=Nucleic Acids Res. |volume=14 |issue= 19 |pages= 7817 |year= 1986 |pmid= 2877435 |doi=
*cite journal | author=Norment AM, Littman DR |title=A second subunit of CD8 is expressed in human T cells. |journal=EMBO J. |volume=7 |issue= 11 |pages= 3433–9 |year= 1989 |pmid= 3145195 |doi=
*cite journal | author=Littman DR, Thomas Y, Maddon PJ, "et al." |title=The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. |journal=Cell |volume=40 |issue= 2 |pages= 237–46 |year= 1985 |pmid= 3871356 |doi=
*cite journal | author=Sukhatme VP, Sizer KC, Vollmer AC, "et al." |title=The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. |journal=Cell |volume=40 |issue= 3 |pages= 591–7 |year= 1985 |pmid= 3918796 |doi=
*cite journal | author=Parnes JR, Sizer KC, Sukhatme VP, Hunkapiller T |title=Structure of Leu-2/T8 as deduced from the sequence of a cDNA clone. |journal=Behring Inst. Mitt. |volume= |issue= 77 |pages= 48–55 |year= 1986 |pmid= 3936473 |doi=

External links

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