CD8

CD8

protein
Name = CD8a molecule
caption =


width =
HGNCid = 1706
Symbol = CD8A
AltSymbols = CD8
EntrezGene = 925
OMIM = 186910
RefSeq = NM_001768
UniProt = P01732
PDB =
ECnumber =
Chromosome = 2
Arm = p
Band = 12
LocusSupplementaryData =
protein
Name = CD8b molecule
caption =


width =
HGNCid = 1707
Symbol = CD8B
AltSymbols = CD8B1
EntrezGene = 926
OMIM = 186730
RefSeq = NM_172099
UniProt = P10966
PDB =
ECnumber =
Chromosome = 2
Arm = p
Band = 12
LocusSupplementaryData =

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. [cite journal |author=Gao G, Jakobsen B |title=Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor |journal=Immunol Today |volume=21 |issue=12 |pages=630–6 |year=2000 |pmid=11114424 |doi=10.1016/S0167-5699(00)01750-3] It is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-α and CD8-β chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Less-common homodimers of the CD8-α chain are also expressed on some cells. The extracellular IgV-like domain of CD8-α interacts with to the α3 portion of the Class I MHC molecule. [cite journal |author=Devine L, Sun J, Barr M, Kavathas P |title=Orientation of the Ig domains of CD8 alpha beta relative to MHC class I |journal=J Immunol |volume=162 |issue=2 |pages=846–51 |year=1999 |pmid=9916707] This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • CD8 — Rezeptor Der CD8 Rezeptor oder einfach nur CD8 ist ein Erkennungsmolekül, das eine wesentliche Rolle im Immunsystem eines höheren Organismus spielt. Es handelt sich dabei um ein Protein, welches in die Zellmembran von cytotoxischen T Killerzellen …   Deutsch Wikipedia

  • CD8 — Saltar a navegación, búsqueda molécula CD8A Identificadores Símbolo CD8A Símbolos alt. CD8 Entrez 925 …   Wikipedia Español

  • CD8 — Símbolo de los linfocitos T periféricos que segregan grandes cantidades de gamma interferón, una linfocina que participa en las defensas del cuerpo frente a los virus. Mientras que las células T CD4 producen principalmente la linfocina… …   Diccionario médico

  • CD8 — (sē dē ātʹ) n. A glycoprotein on the surface of killer cells that enhances binding with MHC molecules.   [c(luster of) d(ifferentiation antigen) 8.] * * * …   Universalium

  • CD8 — CD8a (Альфа) Кристаллографическая структура молекулы CD8 человека.[1] …   Википедия

  • CD8 — Représentation schématique d un récepteur CD8 Le CD8 (cluster of différenciation 8) est une glycoprotéine qui sert de co récepteur s exprimant à la surface des cellules TC. Les CD8 comportent une chaîne α et une chaîne ß, qui toutes deux… …   Wikipédia en Français

  • CD8 — HIV suppressor cell count * * * CD8 .sē (.)dē āt n, often attrib a glycoprotein found esp. on the surface of cytotoxic T cells that usu. functions to facilitate recognition by cytotoxic T cell receptors of antigens complexed with molecules of a… …   Medical dictionary

  • CD8-Rezeptor — Schema …   Deutsch Wikipedia

  • CD8 cells — CD8+ cells a major classification of T lymphocytes, referring to those that carry the CD8 antigen; major subtypes are the cytotoxic T lymphocytes and the suppressor cells. Called also CD8 T lymphocytes …   Medical dictionary

  • CD8 T lymphocytes — CD8+ T lymphocytes CD8 cells …   Medical dictionary

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”