CD226

CD226 molecule
Identifiers
Symbols	CD226; DNAM-1; DNAM1; PTA1; TLiSA1
External IDs	OMIM: 605397 MGI: 3039602 HomoloGene: 4787 GeneCards: CD226 Gene
Gene Ontology Molecular function • receptor activity • integrin binding • protein kinase binding • cell adhesion molecule binding Cellular component • plasma membrane • integral to plasma membrane • cell surface • membrane raft Biological process • cytokine production • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • positive regulation of immunoglobulin mediated immune response • cell adhesion • signal transduction • cell recognition • positive regulation of mast cell activation • positive regulation of natural killer cell mediated cytotoxicity • regulation of immune response • positive regulation of Fc receptor mediated stimulatory signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10666	225825
Ensembl	ENSG00000150637	ENSMUSG00000034028
UniProt	Q15762	Q5DW69
RefSeq (mRNA)	NM_006566	NM_001039148
RefSeq (protein)	NP_006557	NP_001034237
Location (UCSC)	Chr 18: 67.53 – 67.62 Mb	Chr 18: 89.37 – 89.44 Mb
PubMed search	[1]	[2]

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')^[1] or DNAM-1 (protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.^[2]

Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,^[3][4] and cross-linking CD226 with antibodies causes cellular activation.^[2]

See also

• Cluster of differentiation
• Nectin

References

1. ^ ^{a b} Fuchs, Anja; Colonna, M (2006-10). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340. 
2. ^ ^{a b} "Entrez Gene: CD226 CD226 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10666. 
3. ^ Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2194180. 
4. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383. 

Further reading

• Shibuya A, Campbell D, Hannum C, et al. (1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes.". Immunity 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704. 
• Shibuya K, Lanier LL, Phillips JH, et al. (2000). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.". Immunity 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Kojima H, Kanada H, Shimizu S, et al. (2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells.". J. Biol. Chem. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109. 
• Shibuya K, Shirakawa J, Kameyama T, et al. (2004). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation.". J. Exp. Med. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMC 2194159. PMID 14676297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2194159. 
• Reymond N, Imbert AM, Devilard E, et al. (2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions.". J. Exp. Med. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMC 2211807. PMID 15136589. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2211807. 
• Ralston KJ, Hird SL, Zhang X, et al. (2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large.". J. Biol. Chem. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Pende D, Spaggiari GM, Marcenaro S, et al. (2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).". Blood 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144. 
• Pende D, Bottino C, Castriconi R, et al. (2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis.". Mol. Immunol. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800. 
• Tao D, Shangwu L, Qun W, et al. (2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus.". J. Immunol. 174 (3): 1281–90. PMID 15661884. 
• Ma D, Sun Y, Lin D, et al. (2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization.". Eur. J. Haematol. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793. 
• Storojeva I, Boulay JL, Ballabeni P, et al. (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer.". Oncology 68 (2–3): 246–55. doi:10.1159/000086781. PMID 16015041. 
• Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". J. Biol. Chem. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868. 
• Jian JL, Zhu CS, Xu ZW, et al. (2006). "Identification and characterization of the CD226 gene promoter". J. Biol. Chem. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814. 
• Ye X, Zhang Z, Jiang Y, et al. (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients". Viral Immunol. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076. 
• El-Sherbiny YM, Meade JL, Holmes TD, et al. (2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Res. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681. 

External links

• MeSH CD226+protein,+human