CD79

CD79

protein
Name= CD79a molecule, immunoglobulin-associated alpha
caption=


width=
HGNCid=1698
Symbol=CD79A
AltSymbols=IGA
EntrezGene=973
OMIM=112205
RefSeq=NM_001783
UniProt=P11912
PDB=
ECnumber=
Chromosome=19
Arm=q
Band=13.2
LocusSupplementaryData=protein
Name= CD79b molecule, immunoglobulin-associated beta
caption=


width=
HGNCid=1699
Symbol=CD79B
AltSymbols=IGB
EntrezGene=974
OMIM=147245
RefSeq=NM_021602
UniProt=P40259
PDB=
ECnumber=
Chromosome=17
Arm=q
Band=23
LocusSupplementaryData=

CD79 (Cluster of Differentiation 79) is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following recognition of antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (formerly known as Ig-alpha and Ig-beta); these form a heterodimer on the surface of a B cell stabilized by disulfide bonding.cite journal |author=Chu P, Arber D |title=CD79: a review |journal=Appl Immunohistochem Mol Morphol |volume=9 |issue=2 |pages=97–106 |year=2001 |pmid=11396639 |doi=10.1097/00022744-200106000-00001] CD79a and CD79b are both members of the immunoglobulin superfamily. Human CD79a is encoded by the "mb-1" gene that is located on chromosome 19, and CD79b is encoded by the "B29" gene that located on chromosome 17. [cite journal |author=Van Noesel C, Brouns G, van Schijndel G, Bende R, Mason D, Borst J, van Lier R |title=Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers |journal=J Exp Med |volume=175 |issue=6 |pages=1511–9 |year=1992 |pmid=1375264 |doi=10.1084/jem.175.6.1511] Both CD79 chains contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails that they use to propagate a signal in a B cell, in a similar manner to CD3 generated signal tranduction observed during T cell receptor activation on T cells. [cite journal |author=Müller B, Cooper L, Terhorst C |title=Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29) |journal=Immunol Lett |volume=44 |issue=2-3 |pages=97–103 |year=1995 |pmid=7541024 |doi=10.1016/0165-2478(94)00199-2]

ee also

* Cluster of differentiation

References

External links

*


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