GGT1

Gamma-glutamyltransferase 1, (GGT1) also known as CD224 (Cluster of Differentiation 224 ), is a human gene.cite web | title = Entrez Gene: GGT1 gamma-glutamyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2678| accessdate = ]

PBB_Summary
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summary_text = Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.cite web | title = Entrez Gene: GGT1 gamma-glutamyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2678| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chikhi N, Holic N, Guellaen G, Laperche Y |title=Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species. |journal=Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |volume=122 |issue= 4 |pages= 367–80 |year= 1999 |pmid= 10392451 |doi=
*cite journal | author=Indirani N, Hill PG |title=Partial purification and some properties of gamma-glutamyl transpeptidase from human bile. |journal=Biochim. Biophys. Acta |volume=483 |issue= 1 |pages= 57–62 |year= 1977 |pmid= 18198 |doi=
*cite journal | author=Tate SS, Ross ME |title=Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit. |journal=J. Biol. Chem. |volume=252 |issue= 17 |pages= 6042–5 |year= 1977 |pmid= 19463 |doi=
*cite journal | author=Welbourne TC |title=Cytoplasmic gamma-glutamyltransferase: isolation, product formation and physiological role. |journal=Current problems in clinical biochemistry |volume=8 |issue= |pages= 201–15 |year= 1978 |pmid= 28899 |doi=
*cite journal | author=Courtay C, Oster T, Michelet F, "et al." |title=Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues. |journal=Biochem. Pharmacol. |volume=43 |issue= 12 |pages= 2527–33 |year= 1992 |pmid= 1378736 |doi=
*cite journal | author=Pawlak A, Cohen EH, Octave JN, "et al." |title=An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues. |journal=J. Biol. Chem. |volume=265 |issue= 6 |pages= 3256–62 |year= 1990 |pmid= 1968061 |doi=
*cite journal | author=Pitot HC, Goodspeed D, Dunn T, "et al." |title=Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis. |journal=Toxicol. Appl. Pharmacol. |volume=97 |issue= 1 |pages= 23–34 |year= 1989 |pmid= 2563599 |doi=
*cite journal | author=Goodspeed DC, Dunn TJ, Miller CD, Pitot HC |title=Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat. |journal=Gene |volume=76 |issue= 1 |pages= 1–9 |year= 1989 |pmid= 2568315 |doi=
*cite journal | author=Pawlak A, Wu SJ, Bulle F, "et al." |title=Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney. |journal=Biochem. Biophys. Res. Commun. |volume=164 |issue= 2 |pages= 912–8 |year= 1989 |pmid= 2573352 |doi=
*cite journal | author=Laperche Y, Bulle F, Aissani T, "et al." |title=Molecular cloning and nucleotide sequence of rat kidney gamma-glutamyl transpeptidase cDNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 4 |pages= 937–41 |year= 1986 |pmid= 2869484 |doi=
*cite journal | author=Bulle F, Mattei MG, Siegrist S, "et al." |title=Assignment of the human gamma-glutamyl transferase gene to the long arm of chromosome 22. |journal=Hum. Genet. |volume=76 |issue= 3 |pages= 283–6 |year= 1987 |pmid= 2885259 |doi=
*cite journal | author=Tate SS, Khadse V, Wellner D |title=Renal gamma-glutamyl transpeptidases: structural and immunological studies. |journal=Arch. Biochem. Biophys. |volume=262 |issue= 2 |pages= 397–408 |year= 1988 |pmid= 2896486 |doi=
*cite journal | author=Tate SS, Galbraith RA |title=In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase. |journal=Biochem. Biophys. Res. Commun. |volume=154 |issue= 3 |pages= 1167–73 |year= 1988 |pmid= 2900635 |doi=
*cite journal | author=Rajpert-De Meyts E, Heisterkamp N, Groffen J |title=Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 23 |pages= 8840–4 |year= 1988 |pmid= 2904146 |doi=
*cite journal | author=Sakamuro D, Yamazoe M, Matsuda Y, "et al." |title=The primary structure of human gamma-glutamyl transpeptidase. |journal=Gene |volume=73 |issue= 1 |pages= 1–9 |year= 1989 |pmid= 2907498 |doi=
*cite journal | author=Ikeda Y, Fujii J, Anderson ME, "et al." |title=Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22223–8 |year= 1995 |pmid= 7673200 |doi=
*cite journal | author=Wetmore LA, Gerard C, Drazen JM |title=Human lung expresses unique gamma-glutamyl transpeptidase transcripts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 16 |pages= 7461–5 |year= 1993 |pmid= 7689219 |doi=
*cite journal | author=Ikeda Y, Fujii J, Taniguchi N, Meister A |title=Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit. |journal=J. Biol. Chem. |volume=270 |issue= 21 |pages= 12471–5 |year= 1995 |pmid= 7759490 |doi=
*cite journal | author=Courtay C, Heisterkamp N, Siest G, Groffen J |title=Expression of multiple gamma-glutamyltransferase genes in man. |journal=Biochem. J. |volume=297 ( Pt 3) |issue= |pages= 503–8 |year= 1994 |pmid= 7906515 |doi=
*cite journal | author=Ikeda Y, Fujii J, Taniguchi N |title=Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis. |journal=J. Biol. Chem. |volume=268 |issue= 6 |pages= 3980–5 |year= 1993 |pmid= 8095045 |doi=

External links

*

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