C-C chemokine receptor type 6

C-C chemokine receptor type 6

Chemokine receptor 6 (gene name CCR6) is a human CC chemokine receptor.

CCR6 has also recently been designated CD196 (cluster of differentiation 196).

section_title =
summary_text = This protein belongs to family A of G protein-coupled receptor superfamily. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [cite web | title = Entrez Gene: CCR6 chemokine (C-C motif) receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1235| accessdate = ]


Further reading

citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zaballos A, Varona R, Gutiérrez J, "et al." |title=Molecular cloning and RNA expression of two new human chemokine receptor-like genes. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 3 |pages= 846–53 |year= 1996 |pmid= 8886020 |doi= 10.1006/bbrc.1996.1595
*cite journal | author=Liao F, Lee HH, Farber JM |title=Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. |journal=Genomics |volume=40 |issue= 1 |pages= 175–80 |year= 1997 |pmid= 9070937 |doi= 10.1006/geno.1996.4544
*cite journal | author=Baba M, Imai T, Nishimura M, "et al." |title=Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14893–8 |year= 1997 |pmid= 9169459 |doi=
*cite journal | author=Wagner T, Tommerup N, Wirth J, "et al." |title=A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 172–5 |year= 1997 |pmid= 9186513 |doi=
*cite journal | author=Liao F, Alderson R, Su J, "et al." |title=STRL22 is a receptor for the CC chemokine MIP-3alpha. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 1 |pages= 212–7 |year= 1997 |pmid= 9223454 |doi= 10.1006/bbrc.1997.6936
*cite journal | author=Power CA, Church DJ, Meyer A, "et al." |title=Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells. |journal=J. Exp. Med. |volume=186 |issue= 6 |pages= 825–35 |year= 1997 |pmid= 9294137 |doi=
*cite journal | author=Greaves DR, Wang W, Dairaghi DJ, "et al." |title=CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells. |journal=J. Exp. Med. |volume=186 |issue= 6 |pages= 837–44 |year= 1997 |pmid= 9294138 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Yang D, Chertov O, Bykovskaia SN, "et al." |title=Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. |journal=Science |volume=286 |issue= 5439 |pages= 525–8 |year= 1999 |pmid= 10521347 |doi=
*cite journal | author=Krzysiek R, Lefevre EA, Bernard J, "et al." |title=Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha/CCL20 in human B cells. |journal=Blood |volume=96 |issue= 7 |pages= 2338–45 |year= 2000 |pmid= 11001880 |doi=
*cite journal | author=Douglas GC, Thirkill TL, Sideris V, "et al." |title=Chemokine receptor expression by human syncytiotrophoblast. |journal=J. Reprod. Immunol. |volume=49 |issue= 2 |pages= 97–114 |year= 2001 |pmid= 11164896 |doi=
*cite journal | author=Biragyn A, Surenhu M, Yang D, "et al." |title=Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6644–53 |year= 2002 |pmid= 11714836 |doi=
*cite journal | author=Ebert LM, McColl SR |title=Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 65–72 |year= 2002 |pmid= 11751947 |doi=
*cite journal | author=Liao F, Shirakawa AK, Foley JF, "et al." |title=Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding. |journal=J. Immunol. |volume=168 |issue= 10 |pages= 4871–80 |year= 2002 |pmid= 11994436 |doi=
*cite journal | author=Hosokawa Y, Nakanishi T, Yamaguchi D, "et al." |title=Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. |journal=Clin. Exp. Immunol. |volume=128 |issue= 3 |pages= 548–54 |year= 2002 |pmid= 12067311 |doi=
*cite journal | author=Kim CH, Johnston B, Butcher EC |title=Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. |journal=Blood |volume=100 |issue= 1 |pages= 11–6 |year= 2002 |pmid= 12070001 |doi= 10.1182/blood-2001-12-0196
*cite journal | author=Ai LS, Liao F |title=Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling. |journal=Biochemistry |volume=41 |issue= 26 |pages= 8332–41 |year= 2002 |pmid= 12081481 |doi=
*cite journal | author=Hoover DM, Boulegue C, Yang D, "et al." |title=The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37647–54 |year= 2002 |pmid= 12149255 |doi= 10.1074/jbc.M203907200
*cite journal | author=Maki W, Morales RE, Carroll VA, "et al." |title=CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2346–53 |year= 2002 |pmid= 12193700 |doi=

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