C-C chemokine receptor type 7

C-C chemokine receptor type 7
Chemokine (C-C motif) receptor 7
Symbols CCR7; BLR2; CD197; CDw197; CMKBR7; EBI1
External IDs OMIM600242 MGI103011 HomoloGene1387 IUPHAR: CCR7 GeneCards: CCR7 Gene
RNA expression pattern
PBB GE CCR7 206337 at tn.png
More reference expression data
Species Human Mouse
Entrez 1236 12775
Ensembl ENSG00000126353 ENSMUSG00000037944
UniProt P32248 Q3U3J0
RefSeq (mRNA) NM_001838.3 NM_007719.2
RefSeq (protein) NP_001829.1 NP_031745.2
Location (UCSC) Chr 17:
38.71 – 38.72 Mb
Chr 11:
99.01 – 99.02 Mb
PubMed search [1] [2]

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene.[1]

CCR7 has also recently been designated CD197 (cluster of differentiation 197).

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells home to secondary lympho-organ, such as lympho-nodes, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ELC) has been reported to be a specific ligand of this receptor.[2]


External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

TNF receptor JAK-STAT Ig superfamily
CSF1 · KIT · IL1 (IL1R1, IL1R2· IL18R/IL18R1
IL-17 family
IL-17 (IL17RA, IL17RB, IL17RC, IL17RD, IL17RE)
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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