CD33

CD33

protein
Name = CD33 molecule
caption =


width =
HGNCid = 1659
Symbol = CD33
AltSymbols = SIGLEC3, SIGLEC-3, gp67
EntrezGene = 945
OMIM = 159590
RefSeq = NM_023068
UniProt = P20138
PDB =
ECnumber =
Chromosome = 19
Arm = q
Band = 13.3
LocusSupplementaryData =

CD33 is a transmembrane receptor expressed on cells of monocytic/myeloid lineage. It binds sialic acids, therefore is a member of the SIGLEC family of lectins. The extracellular portion of this receptor contains two immunoglobulin domains (one IgV and one IgC2 domain), placing CD33 within the immunoglobulin superfamily. The intracellular portion of CD33 contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that are implicated in inhibition of cellular activity. [ [http://www.ebi.uniprot.org/uniprot-srv/uniProtView.do?proteinAc=P20138 Myeloid cell surface antigen CD33 precursor - Homo sapiens (Human) ] ]

CD33 is the target of gemtuzumab ozogamicin, a monoclonal antibody-based treated for acute myeloid leukemia.

References


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Look at other dictionaries:

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  • SIGLEC — SIGLECs, short for sialic acid binding Ig like lectins are cell surface receptors and members of the immunoglobulin superfamily (IgSF) that recognize sugars. Their ability to recognize carbohydrates using an immunoglobulin domain places them in… …   Wikipedia

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  • SIGLEC9 — Sialic acid binding Ig like lectin 9, also known as SIGLEC9, is a human gene.cite web | title = Entrez Gene: SIGLEC9 sialic acid binding Ig like lectin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

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