Angiotensin-converting enzyme

Angiotensin-converting enzyme

Angiotensin I converting enzyme (ACE, EC number|3.4.15.1) is an exopeptidase.

Functions

It has two primary functions:
* it catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. [GeorgiaPhysiology|7/7ch09/7ch09p16]
* it is involved in the inactivation of bradykinin, a potent vasodilator.

These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.

ynonyms

ACE is also known as:
* "peptidyl dipeptidase A"
* "carboxycathepsin"
* kininase II (kinin-kallikrein system)
* CD 143
* ACE1

Genetics

The ACE gene, "ACE", encodes 2 isozymes. The somatic isozyme is expressed in many tissues, mainly in the lung, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.

ee also

* Renin-angiotensin system
* ACE inhibitors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Niu T, Chen X, Xu X |title=Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications |journal=Drugs |volume=62 |issue= 7 |pages= 977–93 |year= 2002 |pmid= 11985486| doi=10.2165/00003495-200262070-00001
*cite journal | author=Roĭtberg GE, Tikhonravov AV, Dorosh ZhV |title= [Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome] |journal=Ter. Arkh. |volume=75 |issue= 12 |pages= 72–7 |year= 2004 |pmid= 14959477 |doi=
*cite journal | author=Vynohradova SV |title= [The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders in patients with cardiovascular pathology] |journal=Tsitol. Genet. |volume=39 |issue= 1 |pages= 63–70 |year= 2005 |pmid= 16018179 |doi=
*cite journal | author=König S, Luger TA, Scholzen TE |title=Monitoring neuropeptide-specific proteases: processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin |journal=Exp. Dermatol. |volume=15 |issue= 10 |pages= 751–61 |year= 2006 |pmid= 16984256 |doi= 10.1111/j.1600-0625.2006.00472.x
*cite journal | author=Sabbagh AS, Otrock ZK, Mahfoud ZR, "et al." |title=Angiotensin-converting enzyme gene polymorphism and allele frequencies in the Lebanese population: prevalence and review of the literature |journal=Mol. Biol. Rep. |volume=34 |issue= 1 |pages= 47–52 |year= 2007 |pmid= 17103020 |doi= 10.1007/s11033-006-9013-y
*cite journal | author=Castellon R, Hamdi HK |title=Demystifying the ACE polymorphism: from genetics to biology |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1191–8 |year= 2007 |pmid= 17504229| doi=10.2174/138161207780618902
*cite journal | author=Lazartigues E, Feng Y, Lavoie JL |title=The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1231–45 |year= 2007 |pmid= 17504232| doi=10.2174/138161207780618911

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Angiotensin-converting enzyme 2 — Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide [Angiotensin|angiotensin [1 9] .cite journal | author = Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano …   Wikipedia

  • Angiotensin Converting Enzyme — Vorhandene Strukturdaten: 1o86 …   Deutsch Wikipedia

  • angiotensin converting enzyme — noun proteolytic enzyme that converts angiotensin I into angiotensin II • Syn: ↑angiotensin converting enzyme, ↑ACE • Hypernyms: ↑protease, ↑peptidase, ↑proteinase, ↑proteolytic enzyme * * * noun …   Useful english dictionary

  • angiotensin-converting enzyme — noun proteolytic enzyme that converts angiotensin I into angiotensin II • Syn: ↑angiotensin converting enzyme, ↑ACE • Hypernyms: ↑protease, ↑peptidase, ↑proteinase, ↑proteolytic enzyme …   Useful english dictionary

  • angiotensin converting enzyme inhibitor — n ACE INHIBITOR …   Medical dictionary

  • angiotensin-converting enzyme inhibitor — noun an antihypertensive drug that blocks the formation of angiotensin II in the kidney, leading to relaxation of the arteries; promotes the excretion of salt and water by inhibiting the activity of the angiotensin converting enzyme; also used to …   Useful english dictionary

  • angiotensin-converting enzyme inhibitors — competitive inhibitors of peptidyl dipeptidase A (angiotensin converting enzyme), used for treatment of hypertension, usually in conjunction with a diuretic. They are effective in both renovascular and essential low renin hypertension. They are… …   Medical dictionary

  • angiotensin-converting enzyme inhibitor — ACE inhibitor. A drug that is used to lower blood pressure. An angiotensin converting enzyme inhibitor is a type of antihypertensive agent. Also called ACE inhibitor …   English dictionary of cancer terms

  • angiotensin converting enzyme — angiotensin con·vert·ing enzyme kən .vərt iŋ n a proteolytic enzyme that converts angiotensin I to angiotensin II see ACE INHIBITOR …   Medical dictionary

  • angiotensin converting enzyme — noun Date: 1960 a proteolytic enzyme that converts the physiologically inactive form of angiotensin to the active vasoconstrictive form …   New Collegiate Dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”