Angiotensin-converting enzyme 2

Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide [Angiotensin|angiotensin [1-9] .cite journal | author = Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S | title = A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 | journal = Circ. Res. | volume = 87 | issue = 5 | pages = E1–9 | year = 2000 | pmid = 10969042 | doi = | issn = | url _ http://circres.ahajournals.org/cgi/content/abstract/87/5/e1 ] ACE 2 has direct effects on cardiac functionref_N|2|a, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.cite journal | author = Boehm M, Nabel EG | title = Angiotensin-converting enzyme 2--a new cardiac regulator | journal = N. Engl. J. Med. | volume = 347 | issue = 22 | pages = 1795–7 | year = 2002 | pmid = 12456857 | doi = 10.1056/NEJMcibr022472 | issn = ]

ee also

* Renin-angiotensin system
* ACE inhibitors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Turner AJ, Tipnis SR, Guy JL, "et al." |title=ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. |journal=Can. J. Physiol. Pharmacol. |volume=80 |issue= 4 |pages= 346–53 |year= 2002 |pmid= 12025971 |doi=
*cite journal | author=Turner AJ, Hiscox JA, Hooper NM |title=ACE2: from vasopeptidase to SARS virus receptor. |journal=Trends Pharmacol. Sci. |volume=25 |issue= 6 |pages= 291–4 |year= 2004 |pmid= 15165741 |doi= 10.1016/j.tips.2004.04.001
*cite journal | author=Katovich MJ, Grobe JL, Huentelman M, Raizada MK |title=Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. |journal=Exp. Physiol. |volume=90 |issue= 3 |pages= 299–305 |year= 2005 |pmid= 15640278 |doi= 10.1113/expphysiol.2004.028522
*cite journal | author=Ferrario CM, Trask AJ, Jessup JA |title=Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=289 |issue= 6 |pages= H2281–90 |year= 2006 |pmid= 16055515 |doi= 10.1152/ajpheart.00618.2005
*cite journal | author=Jia HP, Look DC, Hickey M, "et al." |title=Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. |journal=Adv. Exp. Med. Biol. |volume=581 |issue= |pages= 479–84 |year= 2006 |pmid= 17037581 |doi=
*cite journal | author=Lazartigues E, Feng Y, Lavoie JL |title=The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. |journal=Curr. Pharm. Des. |volume=13 |issue= 12 |pages= 1231–45 |year= 2007 |pmid= 17504232 |doi=
*cite journal | author=Raizada MK, Ferreira AJ |title=ACE2: a new target for cardiovascular disease therapeutics. |journal=J. Cardiovasc. Pharmacol. |volume=50 |issue= 2 |pages= 112–9 |year= 2007 |pmid= 17703127 |doi= 10.1097/FJC.0b013e3180986219
*cite journal | author=Dean RG, Burrell LM |title=ACE2 and diabetic complications. |journal=Curr. Pharm. Des. |volume=13 |issue= 26 |pages= 2730–5 |year= 2007 |pmid= 17897017 |doi=
*cite journal | author=Tipnis SR, Hooper NM, Hyde R, "et al." |title=A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33238–43 |year= 2000 |pmid= 10924499 |doi= 10.1074/jbc.M002615200
*cite journal | author=Donoghue M, Hsieh F, Baronas E, "et al." |title=A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. |journal=Circ. Res. |volume=87 |issue= 5 |pages= E1–9 |year= 2000 |pmid= 10969042 |doi=
*cite journal | author=Vickers C, Hales P, Kaushik V, "et al." |title=Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14838–43 |year= 2002 |pmid= 11815627 |doi= 10.1074/jbc.M200581200
*cite journal | author=Crackower MA, Sarao R, Oudit GY, "et al." |title=Angiotensin-converting enzyme 2 is an essential regulator of heart function. |journal=Nature |volume=417 |issue= 6891 |pages= 822–8 |year= 2002 |pmid= 12075344 |doi= 10.1038/nature00786
*cite journal | author=Harmer D, Gilbert M, Borman R, Clark KL |title=Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. |journal=FEBS Lett. |volume=532 |issue= 1-2 |pages= 107–10 |year= 2003 |pmid= 12459472 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Donoghue M, Wakimoto H, Maguire CT, "et al." |title=Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 9 |pages= 1043–53 |year= 2004 |pmid= 12967627 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Li W, Moore MJ, Vasilieva N, "et al." |title=Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. |journal=Nature |volume=426 |issue= 6965 |pages= 450–4 |year= 2003 |pmid= 14647384 |doi= 10.1038/nature02145
*cite journal | author=Wong SK, Li W, Moore MJ, "et al." |title=A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3197–201 |year= 2004 |pmid= 14670965 |doi= 10.1074/jbc.C300520200
*cite journal | author=Towler P, Staker B, Prasad SG, "et al." |title=ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17996–8007 |year= 2004 |pmid= 14754895 |doi= 10.1074/jbc.M311191200

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes