CD244

Not to be confused with KIR2DL4.

CD244 molecule, natural killer cell receptor 2B4
Identifiers
Symbols	CD244; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4
External IDs	OMIM: 605554 MGI: 109294 HomoloGene: 9493 GeneCards: CD244 Gene
Gene Ontology Molecular function • receptor activity • protein binding Cellular component • plasma membrane • integral to membrane Biological process • signal transduction • blood coagulation • leukocyte migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51744	18106
Ensembl	ENSG00000122223	n/a
UniProt	Q9BZW8	n/a
RefSeq (mRNA)	NM_001166663.1	NM_018729.2
RefSeq (protein)	NP_001160135.1	NP_061199.2
Location (UCSC)	Chr 1: 160.8 – 160.83 Mb	n/a
PubMed search	[1]	[2]

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.^[1] It is also known as Natural Killer Cell Receptor 2B4^[2]

See also

• Cluster of differentiation

References

1. ^ "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51744. 
2. ^ Online 'Mendelian Inheritance in Man' (OMIM) 605554

Further reading

• Vaidya SV, Mathew PA (2006). "Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells.". Immunol. Lett. 105 (2): 180–4. doi:10.1016/j.imlet.2006.02.006. PMID 16621032. 
• Siu G, Strauss EC, Lai E, Hood LE (1986). "Analysis of a human V beta gene subfamily". J. Exp. Med. 164 (5): 1600–14. doi:10.1084/jem.164.5.1600. PMC 2188445. PMID 3772297. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2188445. 
• Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056. 
• Brown MH, Boles K, van der Merwe PA, et al. (1999). "2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48". J. Exp. Med. 188 (11): 2083–90. doi:10.1084/jem.188.11.2083. PMC 2212392. PMID 9841922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2212392. 
• Tangye SG, Lazetic S, Woollatt E, et al. (1999). "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP". J. Immunol. 162 (12): 6981–5. PMID 10358138. 
• Nakajima H, Cella M, Langen H, et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. doi:10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y. PMID 10359122. 
• Boles KS, Nakajima H, Colonna M, et al. (1999). "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4". Tissue Antigens 54 (1): 27–34. doi:10.1034/j.1399-0039.1999.540103.x. PMID 10458320. 
• Kubin MZ, Parshley DL, Din W, et al. (1999). "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48". Eur. J. Immunol. 29 (11): 3466–77. doi:10.1002/(SICI)1521-4141(199911)29:11<3466::AID-IMMU3466>3.0.CO;2-9. PMID 10556801. 
• Parolini S, Bottino C, Falco M, et al. (2000). "X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells". J. Exp. Med. 192 (3): 337–46. doi:10.1084/jem.192.3.337. PMC 2193227. PMID 10934222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193227. 
• Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript". Immunogenetics 51 (11): 987–92. doi:10.1007/s002510000237. PMID 11003394. 
• Watzl C, Stebbins CC, Long EO (2000). "NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)". J. Immunol. 165 (7): 3545–8. PMID 11034353. 
• Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. doi:10.1016/S0161-5890(00)00076-6. PMID 11163399. 
• Chuang SS, Pham HT, Kumaresan PR, Mathew PA (2001). "A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells". J. Immunol. 166 (10): 6188–95. PMID 11342640. 
• Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068. 
• Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701. 
• Speiser DE, Colonna M, Ayyoub M, et al. (2002). "The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells". J. Immunol. 167 (11): 6165–70. PMID 11714776. 
• Chuang SS, Kumaresan PR, Mathew PA (2002). "2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways". J. Immunol. 167 (11): 6210–6. PMID 11714782. 
• Bottino C, Parolini S, Biassoni R, et al. (2002). "X-linked lymphoproliferative disease: the dark side of 2b4 function". Adv. Exp. Med. Biol. 495: 63–7. PMID 11774610. 
• Aoukaty A, Tan R (2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". J. Biol. Chem. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622. 
• Sivori S, Falco M, Marcenaro E, et al. (2002). "Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4526–31. doi:10.1073/pnas.072065999. PMC 123681. PMID 11917118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=123681. 

External links

• MeSH CD244+protein,+human

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