Killer cell lectin-like receptor subfamily K, member 1

PDB rendering based on 1hyr.
Symbols KLRK1; CD314; D12S2489E; FLJ17759; FLJ75772; KLR; NKG2-D; NKG2D
External IDs OMIM611817 MGI1196250 HomoloGene7209 GeneCards: KLRK1 Gene
Species Human Mouse
Entrez 22914 27007
Ensembl ENSG00000213809 ENSMUSG00000030149
UniProt P26718 Q2TJJ6
RefSeq (mRNA) NM_007360.3 XM_001004553
RefSeq (protein) NP_031386.2 XP_001004553
Location (UCSC) Chr 12:
10.51 – 10.54 Mb
Chr 6:
129.56 – 129.57 Mb
PubMed search [1] [2]

NKG2-D type II integral membrane protein is a protein that in humans is encoded by the KLRK1 gene.[1][2] KLRK1 has also been designated as CD314 (cluster of differentiation 314).

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. D12S2489E is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The first non-coding exon at the 5' end of the D12S2489E transcript is included in the 3' end of the KLRC4 transcript.[3]


  1. ^ Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F (Sep 1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics 48 (3): 163–73. doi:10.1007/s002510050420. PMID 9683661. 
  2. ^ Houchins JP, Yabe T, McSherry C, Bach FH (Apr 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". J Exp Med 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190798. 
  3. ^ "Entrez Gene: KLRK1 killer cell lectin-like receptor subfamily K, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22914. 

Further reading

  • Raulet DH (2003). "Roles of the NKG2D immunoreceptor and its ligands.". Nat. Rev. Immunol. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385. 
  • Lanier LL (2004). "NKG2D.". J. Biol. Regul. Homeost. Agents 17 (4): 338–40. PMID 15065764. 
  • Coudert JD, Held W (2006). "The role of the NKG2D receptor for tumor immunity.". Semin. Cancer Biol. 16 (5): 333–43. doi:10.1016/j.semcancer.2006.07.008. PMID 16914326. 
  • Spertini O, Frei PC (1986). "Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.". Med. Microbiol. Immunol. 175 (4): 229–39. doi:10.1007/BF02123731. PMID 2426565. 
  • Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.". Eur. J. Immunol. 27 (11): 2835–9. doi:10.1002/eji.1830271114. PMID 9394807. 
  • Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306. 
  • Li P, Willie ST, Bauer S, et al. (1999). "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.". Immunity 10 (5): 577–84. doi:10.1016/S1074-7613(00)80057-6. PMID 10367903. 
  • Bauer S, Groh V, Wu J, et al. (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.". Science 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993. 
  • Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994. 
  • Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445. 
  • Diefenbach A, Jamieson AM, Liu SD, et al. (2001). "Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.". Nat. Immunol. 1 (2): 119–26. doi:10.1038/77793. PMID 11248803. 
  • Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.". Nat. Immunol. 2 (5): 443–51. doi:10.1038/87757. PMID 11323699. 
  • Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240–52. PMID 11751968. 
  • Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039–49. doi:10.1016/S1074-7613(01)00241-2. PMID 11754823. 
  • Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671–9. PMID 11777960. 
  • Holmes MA, Li P, Petersdorf EW, Strong RK (2002). "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.". J. Immunol. 169 (3): 1395–400. PMID 12133964. 
  • Groh V, Wu J, Yee C, Spies T (2002). "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.". Nature 419 (6908): 734–8. doi:10.1038/nature01112. PMID 12384702. 
  • Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564. 

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