TNFRSF18

Tumor necrosis factor receptor superfamily, member 18, also known as TNFRSF18, is a human gene.cite web | title = Entrez Gene: TNFRSF18 tumor necrosis factor receptor superfamily, member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8784| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.cite web | title = Entrez Gene: TNFRSF18 tumor necrosis factor receptor superfamily, member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8784| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nocentini G, Giunchi L, Ronchetti S, "et al." |title=A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6216–21 |year= 1997 |pmid= 9177197 |doi=
*cite journal | author=Kwon B, Yu KY, Ni J, "et al." |title=Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6056–61 |year= 1999 |pmid= 10037686 |doi=
*cite journal | author=Gurney AL, Marsters SA, Huang RM, "et al." |title=Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. |journal=Curr. Biol. |volume=9 |issue= 4 |pages= 215–8 |year= 1999 |pmid= 10074428 |doi=
*cite journal | author=Nocentini G, Ronchetti S, Bartoli A, "et al." |title=Identification of three novel mRNA splice variants of GITR. |journal=Cell Death Differ. |volume=7 |issue= 4 |pages= 408–10 |year= 2000 |pmid= 10836847 |doi= 10.1038/sj.cdd.4400670
*cite journal | author=Shimizu J, Yamazaki S, Takahashi T, "et al." |title=Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. |journal=Nat. Immunol. |volume=3 |issue= 2 |pages= 135–42 |year= 2002 |pmid= 11812990 |doi= 10.1038/ni759
*cite journal | author=McHugh RS, Whitters MJ, Piccirillo CA, "et al." |title=CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. |journal=Immunity |volume=16 |issue= 2 |pages= 311–23 |year= 2002 |pmid= 11869690 |doi=
*cite journal | author=Ronchetti S, Nocentini G, Riccardi C, Pandolfi PP |title=Role of GITR in activation response of T lymphocytes. |journal=Blood |volume=100 |issue= 1 |pages= 350–2 |year= 2002 |pmid= 12070049 |doi= 10.1182/blood-2001-12-0276
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Esparza EM, Arch RH |title=Glucocorticoid-induced TNF receptor, a costimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-kappa B activation. |journal=J. Immunol. |volume=174 |issue= 12 |pages= 7875–82 |year= 2005 |pmid= 15944293 |doi=
*cite journal | author=Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, "et al." |title=Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. |journal=Acta Derm. Venereol. |volume=86 |issue= 5 |pages= 393–8 |year= 2006 |pmid= 16955181 |doi= 10.2340/00015555-0118
*cite journal | author=Baltz KM, Krusch M, Bringmann A, "et al." |title=Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. |journal=FASEB J. |volume=21 |issue= 10 |pages= 2442–54 |year= 2007 |pmid= 17360848 |doi= 10.1096/fj.06-7724com
*cite journal | author=Lahey TP, Loisel SD, Wieland-Alter W |title=Glucocorticoid-induced tumor necrosis factor receptor family-related protein triggering enhances HIV-specific CD4+ T cell cytokine secretion and protects HIV-specific CD4+ T cells from apoptosis. |journal=J. Infect. Dis. |volume=196 |issue= 1 |pages= 43–9 |year= 2007 |pmid= 17538882 |doi= 10.1086/518613

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