CD98

protein
Name = solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
caption =


width =
HGNCid = 11026
Symbol = SLC3A2
AltSymbols = MDU1, 4T2HC, 4F2, NACAE
EntrezGene = 6520
OMIM = 158070
RefSeq = NM_001013251
UniProt = P08195
PDB =
ECnumber =
Chromosome = 11
Arm = q
Band = 12
LocusSupplementaryData = -q22protein
Name = solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
caption =


width =
HGNCid = 11063
Symbol = SLC7A5
AltSymbols = LAT1, E16, D16S469E, MPE16, CD98
EntrezGene = 8140
OMIM = 600182
RefSeq = NM_003486
UniProt = Q01650
PDB =
ECnumber =
Chromosome = 16
Arm = q
Band = 24.3
LocusSupplementaryData =

CD98 is a glycoproteincite journal | author = Kucharzik T, Lugering A, Yan Y, Driss A, Charrier L, Sitaraman S, Merlin D | title = Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation | journal = Lab. Invest. | volume = 85 | issue = 7 | pages = 932–41 | year = 2005 | pmid = 15880135 | doi = 10.1038/labinvest.3700289 | issn = ] cite journal | author = Lemaître G, Gonnet F, Vaigot P, Gidrol X, Martin MT, Tortajada J, Waksman G | title = CD98, a novel marker of transient amplifying human keratinocytes | journal = Proteomics | volume = 5 | issue = 14 | pages = 3637–45 | year = 2005 | pmid = 16097038 | doi = 10.1002/pmic.200401224 | issn = ] that comprises the light subunit of the Large neutral Amino acid Transporter (LAT1). LAT1 is a heterodimeric membrane transport protein that preferentially transports neutral branched (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.cite journal | author = Boado RJ, Li JY, Nagaya M, Zhang C, Pardridge WM | title = Selective expression of the large neutral amino acid transporter at the blood-brain barrier | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 21 | pages = 12079–84 | year = 1999 | pmid = 10518579 | doi = 10.1073/pnas.96.21.12079 | issn = ] LAT is highly expressed in brain capillaries (which form the blood brain barrier) relative to other tissues.

Functional LAT1 transporters are comprised of two proteins encoded by two distinct genes:
* 4F2hc heavy subunit protein encoded by the SLC3A2 gene cite journal |author=Palacin M, Kanai Y|title=The ancillary proteins of HATs: SLC3 family of amino acid transporters|journal= Pflugers Arch |volume= 447 |issue= 5 |pages= 490–494 |year= 2004|doi= 10.1007/s00424-003-1062-7 |pmid= 14770309]
* CD98 light subunit protein encoded by the SLC7A5 genecite journal |author=Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y |title=CATs and HATs: the SLC7 family of amino acid transporters |journal= Pflugers Arch |volume= 447 |issue= 5 |pages= 532–542 |year= 2004 |doi = 10.1007/s00424-003-1086-z |pmid= 14770310]

ee also

* Cluster of differentiation
* Transmembrane protein
* Transport protein
* Solute carrier family

References

External links

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