[cite web | title = Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27087| accessdate = ] ] PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.[cite web | title = Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27087| accessdate = ] ]
In immunology, the CD57 antigen (CD stands for cluster of differentiation) is a protein which is also called HNK1 (human natural killer-1) or LEU7. It is a neuronally expressed adhesion molecule with a carbohydrate epitope that contains a sulfoglucuronyl residue.[cite journal | author = Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T | title = Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope | journal = Genomics | volume = 65 | issue = 2 | pages = 166–73 | year = 2000 | pmid = 10783264 | doi = 10.1006/geno.2000.6152 | issn = ] ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Tone Y, Kitagawa H, Imiya K, "et al." |title=Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. |journal=FEBS Lett. |volume=459 |issue= 3 |pages= 415–20 |year= 1999 |pmid= 10526176 |doi=
*cite journal | author=Mitsumoto Y, Oka S, Sakuma H, "et al." |title=Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope. |journal=Genomics |volume=65 |issue= 2 |pages= 166–73 |year= 2000 |pmid= 10783264 |doi= 10.1006/geno.2000.6152
*cite journal | author=Pedersen LC, Tsuchida K, Kitagawa H, "et al." |title=Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34580–5 |year= 2000 |pmid= 10946001 |doi= 10.1074/jbc.M007399200
*cite journal | author=Cebo C, Durier V, Lagant P, "et al." |title=Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12246–52 |year= 2002 |pmid= 11788581 |doi= 10.1074/jbc.M106816200
*cite journal | author=Ouzzine M, Gulberti S, Levoin N, "et al." |title=The donor substrate specificity of the human beta 1,3-glucuronosyltransferase I toward UDP-glucuronic acid is determined by two crucial histidine and arginine residues. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25439–45 |year= 2002 |pmid= 11986319 |doi= 10.1074/jbc.M201912200
*cite journal | author=Brenchley JM, Karandikar NJ, Betts MR, "et al." |title=Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. |journal=Blood |volume=101 |issue= 7 |pages= 2711–20 |year= 2003 |pmid= 12433688 |doi= 10.1182/blood-2002-07-2103
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jirásek T, Hozák P, Mandys V |title=Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal carcinoids: immunohistochemical and confocal laser scanning microscopy study. |journal=Neoplasma |volume=50 |issue= 1 |pages= 1–7 |year= 2003 |pmid= 12687271 |doi=
*cite journal | author=Jeffries AR, Mungall AJ, Dawson E, "et al." |title=beta-1,3-Glucuronyltransferase-1 gene implicated as a candidate for a schizophrenia-like psychosis through molecular analysis of a balanced translocation. |journal=Mol. Psychiatry |volume=8 |issue= 7 |pages= 654–63 |year= 2004 |pmid= 12874601 |doi= 10.1038/sj.mp.4001382
*cite journal | author=Chochi K, Ichikura T, Majima T, "et al." |title=The increase of CD57+ T cells in the peripheral blood and their impaired immune functions in patients with advanced gastric cancer. |journal=Oncol. Rep. |volume=10 |issue= 5 |pages= 1443–8 |year= 2004 |pmid= 12883721 |doi=
*cite journal | author=Kakuda S, Shiba T, Ishiguro M, "et al." |title=Structural basis for acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22693–703 |year= 2004 |pmid= 14993226 |doi= 10.1074/jbc.M400622200
*cite journal | author=Matsubara K, Yura K, Hirata T, "et al." |title=Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report. |journal=Pediatric hematology and oncology |volume=21 |issue= 7 |pages= 677–82 |year= 2005 |pmid= 15626024 |doi=
*cite journal | author=Ibegbu CC, Xu YX, Harris W, "et al." |title=Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57. |journal=J. Immunol. |volume=174 |issue= 10 |pages= 6088–94 |year= 2005 |pmid= 15879103 |doi=
*cite journal | author=Assouti M, Vynios DH, Anagnostides ST, "et al." |title=Collagen type IX and HNK-1 epitope in tears of patients with pseudoexfoliation syndrome. |journal=Biochim. Biophys. Acta |volume=1762 |issue= 1 |pages= 54–8 |year= 2006 |pmid= 16257185 |doi= 10.1016/j.bbadis.2005.09.005
*cite journal | author=Barré L, Venkatesan N, Magdalou J, "et al." |title=Evidence of calcium-dependent pathway in the regulation of human beta1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesis. |journal=FASEB J. |volume=20 |issue= 10 |pages= 1692–4 |year= 2006 |pmid= 16807373 |doi= 10.1096/fj.05-5073fje
*cite journal | author=Sada-Ovalle I, Torre-Bouscoulet L, Valdez-Vázquez R, "et al." |title=Characterization of a cytotoxic CD57+ T cell subset from patients with pulmonary tuberculosis. |journal=Clin. Immunol. |volume=121 |issue= 3 |pages= 314–23 |year= 2007 |pmid= 17035093 |doi= 10.1016/j.clim.2006.08.011
External links
*
PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes
