- CD27
CD27 is a
tumor necrosis factor receptor .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [cite web | title = Entrez Gene: CD27 CD27 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=939| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Lens SM, de Jong R, Hintzen RQ, "et al." |title=CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth. |journal=Leuk. Lymphoma |volume=18 |issue= 1-2 |pages= 51–9 |year= 1996 |pmid= 8580829 |doi=
*cite journal | author=Agematsu K |title=Memory B cells and CD27. |journal=Histol. Histopathol. |volume=15 |issue= 2 |pages= 573–6 |year= 2000 |pmid= 10809378 |doi=
*cite journal | author=van Baarle D, Kostense S, van Oers MH, "et al." |title=Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue. |journal=Trends Immunol. |volume=23 |issue= 12 |pages= 586–91 |year= 2003 |pmid= 12464570 |doi=
*cite journal | author=Dörner T, Lipsky PE |title=Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus. |journal=Lupus |volume=13 |issue= 5 |pages= 283–9 |year= 2005 |pmid= 15230280 |doi=External links
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PBB_Controls
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