JAG1

JAG1 is a protein associated with Alagille syndrome. JAG1 has also been designated as CD339 (cluster of differentiation 339).

PBB_Summary
section_title =
summary_text = The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [cite web | title = Entrez Gene: JAG1 jagged 1 (Alagille syndrome)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=182| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Piccoli DA, Spinner NB |title=Alagille syndrome and the Jagged1 gene. |journal=Semin. Liver Dis. |volume=21 |issue= 4 |pages= 525–34 |year= 2002 |pmid= 11745040 |doi= 10.1055/s-2001-19036
*cite journal | author=Lindsell CE, Shawber CJ, Boulter J, Weinmaster G |title=Jagged: a mammalian ligand that activates Notch1. |journal=Cell |volume=80 |issue= 6 |pages= 909–17 |year= 1995 |pmid= 7697721 |doi=
*cite journal | author=Lindsell CE, Boulter J, diSibio G, "et al." |title=Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. |journal=Mol. Cell. Neurosci. |volume=8 |issue= 1 |pages= 14–27 |year= 1997 |pmid= 8923452 |doi= 10.1006/mcne.1996.0040
*cite journal | author=Zimrin AB, Pepper MS, McMahon GA, "et al." |title=An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 51 |pages= 32499–502 |year= 1997 |pmid= 8955070 |doi=
*cite journal | author=Oda T, Elkahloun AG, Pike BL, "et al." |title=Mutations in the human Jagged1 gene are responsible for Alagille syndrome. |journal=Nat. Genet. |volume=16 |issue= 3 |pages= 235–42 |year= 1997 |pmid= 9207787 |doi= 10.1038/ng0797-235
*cite journal | author=Li L, Krantz ID, Deng Y, "et al." |title=Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. |journal=Nat. Genet. |volume=16 |issue= 3 |pages= 243–51 |year= 1997 |pmid= 9207788 |doi= 10.1038/ng0797-243
*cite journal | author=Oda T, Elkahloun AG, Meltzer PS, Chandrasekharappa SC |title=Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12. |journal=Genomics |volume=43 |issue= 3 |pages= 376–9 |year= 1997 |pmid= 9268641 |doi= 10.1006/geno.1997.4820
*cite journal | author=Li L, Milner LA, Deng Y, "et al." |title=The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. |journal=Immunity |volume=8 |issue= 1 |pages= 43–55 |year= 1998 |pmid= 9462510 |doi=
*cite journal | author=Krantz ID, Colliton RP, Genin A, "et al." |title=Spectrum and frequency of jagged1 (JAG1) mutations in Alagille syndrome patients and their families. |journal=Am. J. Hum. Genet. |volume=62 |issue= 6 |pages= 1361–9 |year= 1998 |pmid= 9585603 |doi=
*cite journal | author=Hock B, Böhme B, Karn T, "et al." |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–84 |year= 1998 |pmid= 9707552 |doi=
*cite journal | author=Gray GE, Mann RS, Mitsiadis E, "et al." |title=Human ligands of the Notch receptor. |journal=Am. J. Pathol. |volume=154 |issue= 3 |pages= 785–94 |year= 1999 |pmid= 10079256 |doi=
*cite journal | author=Crosnier C, Driancourt C, Raynaud N, "et al." |title=Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome. |journal=Gastroenterology |volume=116 |issue= 5 |pages= 1141–8 |year= 1999 |pmid= 10220506 |doi=
*cite journal | author=Bash J, Zong WX, Banga S, "et al." |title=Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. |journal=EMBO J. |volume=18 |issue= 10 |pages= 2803–11 |year= 1999 |pmid= 10329626 |doi= 10.1093/emboj/18.10.2803
*cite journal | author=Pilia G, Uda M, Macis D, "et al." |title=Jagged-1 mutation analysis in Italian Alagille syndrome patients. |journal=Hum. Mutat. |volume=14 |issue= 5 |pages= 394–400 |year= 2000 |pmid= 10533065 |doi= 10.1002/(SICI)1098-1004(199911)14:5<394::AID-HUMU5>3.0.CO;2-1 |doilabel=10.1002/(SICI)1098-1004(199911)14:5394::AID-HUMU53.0.CO;2-1
*cite journal | author=Shimizu K, Chiba S, Kumano K, "et al." |title=Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32961–9 |year= 2000 |pmid= 10551863 |doi=
*cite journal | author=Wong MK, Prudovsky I, Vary C, "et al." |title=A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 853–9 |year= 2000 |pmid= 10679295 |doi= 10.1006/bbrc.2000.2173
*cite journal | author=Shimizu K, Chiba S, Hosoya N, "et al." |title=Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6913–22 |year= 2000 |pmid= 10958687 |doi=
*cite journal | author=Shimizu K, Chiba S, Saito T, "et al." |title=Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 385–9 |year= 2000 |pmid= 11006133 |doi= 10.1006/bbrc.2000.3469
*cite journal | author=Heritage ML, MacMillan JC, Colliton RP, "et al." |title=Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population. |journal=Hum. Mutat. |volume=16 |issue= 5 |pages= 408–16 |year= 2000 |pmid= 11058898 |doi= 10.1002/1098-1004(200011)16:5<408::AID-HUMU5>3.0.CO;2-9 |doilabel=10.1002/1098-1004(200011)16:5408::AID-HUMU53.0.CO;2-9
*cite journal | author=Karanu FN, Murdoch B, Gallacher L, "et al." |title=The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. |journal=J. Exp. Med. |volume=192 |issue= 9 |pages= 1365–72 |year= 2000 |pmid= 11067884 |doi=

External links

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