- Erythropoietin receptor
The erythropoietin receptor is a 66 kDa
peptide and is a member of thecytokine receptor family. The receptor istyrosine phosphorylated upon binding byerythropoietin and associates with and activates thetyrosine kinase ,JAK2 , which activates different intracellular pathways including: Ras/MAP kinase,phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produceerythroleukemia andfamilial erythrocytosis . [cite web | title = Entrez Gene: EPOR erythropoietin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2057| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Zhu Y, D'Andrea AD |title=The molecular physiology of erythropoietin and the erythropoietin receptor. |journal=Curr. Opin. Hematol. |volume=1 |issue= 2 |pages= 113–8 |year= 1999 |pmid= 9371269 |doi=
*cite journal | author=Lacombe C, Mayeux P |title=Biology of erythropoietin. |journal=Haematologica |volume=83 |issue= 8 |pages= 724–32 |year= 1998 |pmid= 9793257 |doi=
*cite journal | author=Bonifacino JS |title=Quality control of receptor-kinase signaling complexes. |journal=Dev. Cell |volume=2 |issue= 1 |pages= 1–2 |year= 2002 |pmid= 11782306 |doi=
*cite journal | author=Takeshita A, Shinjo K, Naito K, "et al." |title=Erythropoietin receptor in myelodysplastic syndrome and leukemia. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 261–4 |year= 2003 |pmid= 11999556 |doi=
*cite journal | author=Kralovics R, Skoda RC |title=Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders. |journal=Blood Rev. |volume=19 |issue= 1 |pages= 1–13 |year= 2005 |pmid= 15572213 |doi= 10.1016/j.blre.2004.02.002
*cite journal | author=Madeddu P, Emanueli C |title=Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor. |journal=Circ. Res. |volume=100 |issue= 5 |pages= 599–601 |year= 2007 |pmid= 17363704 |doi= 10.1161/01.RES.0000261610.11754.b1External links
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