CD15

CD15

protein
Name=fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
caption=


width=
HGNCid=4015
Symbol=FUT4
AltSymbols=CD15, FCT3A, ELFT, SSEA-1, LeX
EntrezGene=2526
OMIM=104230
RefSeq=NM_002033
UniProt=P22083
PDB=
ECnumber=
Chromosome=11
Arm=q
Band=21
LocusSupplementaryData=

CD15 (3-fucosyl-N-acetyl-lactosamine) is a cluster of differentiation - an immunologically significant molecule. CD15 is a carbohydrate adhesion molecule (not a protein) that can be expressed on Glycoproteins, Glycolipids and Proteoglycans. It mediates phagocytosis and chemotaxis, found on neutrophils; expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. It is also called Lewis x and SSEA-1 (stage specific embryonic antigen 1) and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo. It is synthezised by FUT 4 (fucosyltransferase 4).

See also

*Sialyl Lewis X


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