Sialyl lewis x

Sialyl lewis x

Chembox new
ImageFile = Sialyl Lewis x.svg
ImageSize = 250px
IUPACName =
OtherNames =
Section1 = Chembox Identifiers
CASNo = 98603-84-0
PubChem = 643990
SMILES =
MeSHName = sialyl+Lewis+x
Section2 = Chembox Properties
Formula = C31H52N2O23
MolarMass = 820.744 g/mol
Appearance =
Density =
MeltingPt =
BoilingPt =
Section3 = Chembox Hazards
Solubility =
MainHazards =
FlashPt =
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Sialyl LewisX, also known as "sialyl LeX" and "SLeX", is a tetrasaccharide carbohydrate, that is usually attached to O-glycans on the surface of the cells, and known to play a vital role in cell-cell recognition processes. "Sialyl Lewis X" is one of the most important blood group antigens and is displayed on the terminus of glycolipids that are present on the cell-surface. "Sialyl Lewis X" determinant, E-selectin ligand carbohydrate structure, is constitutively expressed on granulocytes and monocytes and mediates inflammatory extravasation of these cells. Resting T and B lymphocytes lack its expression and are induced to strongly express "sialyl Lewis X" upon activation. "Sialyl Lewis X" determinant is expressed preferentially on activated Th1 cells but not on Th2 cells.
Defective synthesis of the sialyl Lewis X antigen results in immunodeficiency. Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the glycosphingolipid.

ources

* [http://www.chm.bris.ac.uk/motm/sla/sialyl.html Stephen J Isles, Molecule of the Month: Sialyl Lewis X]
*

See also

*CD15 (Lewis X)


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  • sialyl Lewis x — (= sLex ; CD15s) Sialylated form of CD15, the ligand for E , P and L selectins. Expressed on neutrophils, basophils and monocytes and only some lymphocytes. Also present on some HEV. Deficiency in sialyl Lewis X will cause leucocyte adhesion… …   Dictionary of molecular biology

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  • FUT7 — Fucosyltransferase 7 (alpha (1,3) fucosyltransferase), also known as FUT7, is a human gene.cite web | title = Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • FUT6 — Fucosyltransferase 6 (alpha (1,3) fucosyltransferase), also known as FUT6, is a human gene.cite web | title = Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

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  • FUT5 — Fucosyltransferase 5 (alpha (1,3) fucosyltransferase), also known as FUT5, is a human gene.cite web | title = Entrez Gene: FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • B3GNT2 — UDP GlcNAc:betaGal beta 1,3 N acetylglucosaminyltransferase 2, also known as B3GNT2, is a human gene.cite web | title = Entrez Gene: B3GNT2 UDP GlcNAc:betaGal beta 1,3 N acetylglucosaminyltransferase 2| url =… …   Wikipedia

  • Glycans — The term glycan refers to a polysaccharide or oligosaccharide. Glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan. Glycans usually consist solely of O glycosidic …   Wikipedia

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