Lymphotoxin beta receptor

Lymphotoxin beta receptor

Lymphotoxin beta receptor is a receptor for lymphotoxin.

section_title =
summary_text = The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.cite web | title = Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Elewaut D, Ware CF |title=The unconventional role of LT alpha beta in T cell differentiation. |journal=Trends Immunol. |volume=28 |issue= 4 |pages= 169–75 |year= 2007 |pmid= 17336158 |doi= 10.1016/
*cite journal | author=Browning JL, Ngam-ek A, Lawton P, "et al." |title=Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. |journal=Cell |volume=72 |issue= 6 |pages= 847–56 |year= 1993 |pmid= 7916655 |doi=
*cite journal | author=Crowe PD, VanArsdale TL, Walter BN, "et al." |title=A lymphotoxin-beta-specific receptor. |journal=Science |volume=264 |issue= 5159 |pages= 707–10 |year= 1994 |pmid= 8171323 |doi=
*cite journal | author=Baens M, Chaffanet M, Cassiman JJ, "et al." |title=Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. |journal=Genomics |volume=16 |issue= 1 |pages= 214–8 |year= 1993 |pmid= 8486360 |doi= 10.1006/geno.1993.1161
*cite journal | author=Baens M, Aerssens J, van Zand K, "et al." |title=Isolation and regional assignment of human chromosome 12p cDNAs. |journal=Genomics |volume=29 |issue= 1 |pages= 44–52 |year= 1996 |pmid= 8530100 |doi= 10.1006/geno.1995.1213
*cite journal | author=Wang X, Bornslaeger EA, Haub O, "et al." |title=A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein. |journal=Dev. Biol. |volume=177 |issue= 1 |pages= 274–90 |year= 1996 |pmid= 8660894 |doi= 10.1006/dbio.1996.0162
*cite journal | author=Nakano H, Oshima H, Chung W, "et al." |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661–4 |year= 1996 |pmid= 8663299 |doi=
*cite journal | author=Matsumoto M, Hsieh TY, Zhu N, "et al." |title=Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 2 |pages= 1301–9 |year= 1997 |pmid= 8995654 |doi=
*cite journal | author=VanArsdale TL, VanArsdale SL, Force WR, "et al." |title=Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2460–5 |year= 1997 |pmid= 9122217 |doi=
*cite journal | author=Wu MY, Hsu TL, Lin WW, "et al." |title=Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells. |journal=J. Biol. Chem. |volume=272 |issue= 27 |pages= 17154–9 |year= 1997 |pmid= 9202035 |doi=
*cite journal | author=Chen CM, You LR, Hwang LH, Lee YH |title=Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. |journal=J. Virol. |volume=71 |issue= 12 |pages= 9417–26 |year= 1997 |pmid= 9371602 |doi=
*cite journal | author=Mizushima S, Fujita M, Ishida T, "et al." |title=Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). |journal=Gene |volume=207 |issue= 2 |pages= 135–40 |year= 1998 |pmid= 9511754 |doi=
*cite journal | author=Krajewska M, Krajewski S, Zapata JM, "et al." |title=TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues. |journal=Am. J. Pathol. |volume=152 |issue= 6 |pages= 1549–61 |year= 1998 |pmid= 9626059 |doi=
*cite journal | author=Boussaud V, Soler P, Moreau J, "et al." |title=Expression of three members of the TNF-R family of receptors (4-1BB, lymphotoxin-beta receptor, and Fas) in human lung. |journal=Eur. Respir. J. |volume=12 |issue= 4 |pages= 926–31 |year= 1999 |pmid= 9817170 |doi=
*cite journal | author=Murphy M, Walter BN, Pike-Nobile L, "et al." |title=Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues. |journal=Cell Death Differ. |volume=5 |issue= 6 |pages= 497–505 |year= 1999 |pmid= 10200501 |doi= 10.1038/sj.cdd.4400374
*cite journal | author=Wu MY, Wang PY, Han SH, Hsieh SL |title=The cytoplasmic domain of the lymphotoxin-beta receptor mediates cell death in HeLa cells. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11868–73 |year= 1999 |pmid= 10207006 |doi=
*cite journal | author=Yu KY, Kwon B, Ni J, "et al." |title=A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 13733–6 |year= 1999 |pmid= 10318773 |doi=
*cite journal | author=Rooney IA, Butrovich KD, Glass AA, "et al." |title=The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. |journal=J. Biol. Chem. |volume=275 |issue= 19 |pages= 14307–15 |year= 2000 |pmid= 10799510 |doi=
*cite journal | author=Langeggen H, Berge KE, Johnson E, Hetland G |title=Human umbilical vein endothelial cells express complement receptor 1 (CD35) and complement receptor 4 (CD11c/CD18) in vitro. |journal=Inflammation |volume=26 |issue= 3 |pages= 103–10 |year= 2003 |pmid= 12083416 |doi=
*cite journal | author=Chang YH, Hsieh SL, Chen MC, Lin WW |title=Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation. |journal=Exp. Cell Res. |volume=278 |issue= 2 |pages= 166–74 |year= 2002 |pmid= 12169272 |doi=

External links


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