CDCP1

CUB domain containing protein 1, also known as CDCP1, is a human gene.cite web | title = Entrez Gene: CDCP1 CUB domain containing protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64866| accessdate = ] CDCP1 has also been designated as CD318 (cluster of differentiation 318).

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: CDCP1 CUB domain containing protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64866| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Xia Y, Gil SG, Carter WG |title=Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. |journal=J. Cell Biol. |volume=132 |issue= 4 |pages= 727–40 |year= 1996 |pmid= 8647901 |doi=
*cite journal | author=Scherl-Mostageer M, Sommergruber W, Abseher R, "et al." |title=Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. |journal=Oncogene |volume=20 |issue= 32 |pages= 4402–8 |year= 2001 |pmid= 11466621 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hooper JD, Zijlstra A, Aimes RT, "et al." |title=Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. |journal=Oncogene |volume=22 |issue= 12 |pages= 1783–94 |year= 2003 |pmid= 12660814 |doi= 10.1038/sj.onc.1206220
*cite journal | author=Conze T, Lammers R, Kuci S, "et al." |title=CDCP1 is a novel marker for hematopoietic stem cells. |journal=Ann. N. Y. Acad. Sci. |volume=996 |issue= |pages= 222–6 |year= 2003 |pmid= 12799299 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brown TA, Yang TM, Zaitsevskaia T, "et al." |title=Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 14772–83 |year= 2004 |pmid= 14739293 |doi= 10.1074/jbc.M309678200
*cite journal | author=Bühring HJ, Kuçi S, Conze T, "et al." |title=CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. |journal=Stem Cells |volume=22 |issue= 3 |pages= 334–43 |year= 2005 |pmid= 15153610 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Benes CH, Wu N, Elia AE, "et al." |title=The C2 domain of PKCdelta is a phosphotyrosine binding domain. |journal=Cell |volume=121 |issue= 2 |pages= 271–80 |year= 2005 |pmid= 15851033 |doi= 10.1016/j.cell.2005.02.019
*cite journal | author=Bhatt AS, Erdjument-Bromage H, Tempst P, "et al." |title=Adhesion signaling by a novel mitotic substrate of src kinases. |journal=Oncogene |volume=24 |issue= 34 |pages= 5333–43 |year= 2005 |pmid= 16007225 |doi= 10.1038/sj.onc.1208582
*cite journal | author=André M, Le Caer JP, Greco C, "et al." |title=Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS. |journal=Proteomics |volume=6 |issue= 5 |pages= 1437–49 |year= 2006 |pmid= 16404722 |doi= 10.1002/pmic.200500180
*cite journal | author=Kimura H, Morii E, Ikeda JI, "et al." |title=Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells. |journal=Leukemia |volume=20 |issue= 9 |pages= 1551–6 |year= 2006 |pmid= 16926850 |doi= 10.1038/sj.leu.2404312
*cite journal | author=Perry SE, Robinson P, Melcher A, "et al." |title=Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. |journal=FEBS Lett. |volume=581 |issue= 6 |pages= 1137–42 |year= 2007 |pmid= 17335815 |doi= 10.1016/j.febslet.2007.02.025
*cite journal | author=Uekita T, Jia L, Narisawa-Saito M, "et al." |title=CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. |journal=Mol. Cell. Biol. |volume=27 |issue= 21 |pages= 7649–60 |year= 2007 |pmid= 17785447 |doi= 10.1128/MCB.01246-07

External links

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