Type II cytokine receptor

Type II cytokine receptor

Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors.

tructure

Typically type II cytokine receptors are hetrodimers or multimers with a high and a low affinity component. Currently no complete structure of the extracellular domains of a type II cytokine receptor is available. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.

Types

Type II cytokine receptors include those that bind type I and type II interferons, and those that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22).cite journal |author=Dumoutier L, Lejeune D, Hor S, Fickenscher H, Renauld JC |title=Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3 |journal=Biochem. J. |volume=370 |issue=Pt 2 |pages=391–6 |year=2003 |pmid=12521379 |doi=10.1042/BJ20021935] cite journal |author=Xu W, Presnell SR, Parrish-Novak J, "et al" |title=A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue=17 |pages=9511–6 |year=2001 |pmid=11481447 |doi=10.1073/pnas.171303198]

Interferon receptors

The interferon receptor is a molecule displayed on the surface of cells which allows them to interact with the anti-viral substance interferon. The receptor is genetically coded for by number of different genes, as there are a few distinct types of interferon. Interferon receptor deficiency is a condition showing some amenability to genetic therapy.cite journal | author = Reuter U, Roesler J, Thiede C, Schulz A, Classen CF, Oelschlagel U, Debatin KM, Friedrich W | title = Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation | journal = Blood | volume = 100 | issue = 12 | pages = 4234–5 | year = 2002 | pmid = 12393576 | doi = 10.1182/blood-2002-02-0433 | issn = ]

*interferon-alpha/beta receptor
*interferon-gamma receptor

Interleukin receptors

References


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