[cite web | title = Entrez Gene: CD5 CD5 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=921| accessdate = ] B1 B cells have limited diversity of their B Cell Receptor (BCR) due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B1 cells can only be activated by a very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T cell marker until mABs against CD3 were developed.In humans, the gene is located on the q arm of chromosome 11 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=921] . ]
CD72 serves as a ligand.T cells express higher levels of CD5 than B cells. CD5 is up-regulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Berland R, Wortis HH |title=Origins and functions of B-1 cells with notes on the role of CD5. |journal=Annu. Rev. Immunol. |volume=20 |issue= |pages= 253–300 |year= 2002 |pmid= 11861604 |doi= 10.1146/annurev.immunol.20.100301.064833
*cite journal | author=Osman N, Ley SC, Crumpton MJ |title=Evidence for an association between the T cell receptor/CD3 antigen complex and the CD5 antigen in human T lymphocytes. |journal=Eur. J. Immunol. |volume=22 |issue= 11 |pages= 2995–3000 |year= 1992 |pmid= 1385158 |doi=
*cite journal | author=Van de Velde H, von Hoegen I, Luo W, "et al." |title=The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. |journal=Nature |volume=351 |issue= 6328 |pages= 662–5 |year= 1991 |pmid= 1711157 |doi= 10.1038/351662a0
*cite journal | author=Jones NH, Clabby ML, Dialynas DP, "et al." |title=Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1. |journal=Nature |volume=323 |issue= 6086 |pages= 346–9 |year= 1986 |pmid= 3093892 |doi= 10.1038/323346a0
*cite journal | author=Lankester AC, van Schijndel GM, Cordell JL, "et al." |title=CD5 is associated with the human B cell antigen receptor complex. |journal=Eur. J. Immunol. |volume=24 |issue= 4 |pages= 812–6 |year= 1994 |pmid= 7512031 |doi=
*cite journal | author=Raab M, Yamamoto M, Rudd CE |title=The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck. |journal=Mol. Cell. Biol. |volume=14 |issue= 5 |pages= 2862–70 |year= 1994 |pmid= 7513045 |doi=
*cite journal | author=Dianzani U, Bragardo M, Buonfiglio D, "et al." |title=Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. |journal=Eur. J. Immunol. |volume=25 |issue= 5 |pages= 1306–11 |year= 1995 |pmid= 7539755 |doi=
*cite journal | author=Van de Velde H, Thielemans K |title=Native soluble CD5 delivers a costimulatory signal to resting human B lymphocytes. |journal=Cell. Immunol. |volume=172 |issue= 1 |pages= 84–91 |year= 1996 |pmid= 8806810 |doi= 10.1006/cimm.1996.0218
*cite journal | author=Dennehy KM, Broszeit R, Garnett D, "et al." |title=Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 679–86 |year= 1997 |pmid= 9079809 |doi=
*cite journal | author=Gary-Gouy H, Lang V, Sarun S, "et al." |title=In vivo association of CD5 with tyrosine-phosphorylated ZAP-70 and p21 phospho-zeta molecules in human CD3+ thymocytes. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 3739–47 |year= 1997 |pmid= 9378960 |doi=
*cite journal | author=Dennehy KM, Broszeit R, Ferris WF, Beyers AD |title=Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5. |journal=Eur. J. Immunol. |volume=28 |issue= 5 |pages= 1617–25 |year= 1998 |pmid= 9603468 |doi=
*cite journal | author=Bauch A, Campbell KS, Reth M |title=Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta. |journal=Eur. J. Immunol. |volume=28 |issue= 7 |pages= 2167–77 |year= 1998 |pmid= 9692886 |doi=
*cite journal | author=Calvo J, Vildà JM, Places L, "et al." |title=Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein kinase II. |journal=J. Immunol. |volume=161 |issue= 11 |pages= 6022–9 |year= 1998 |pmid= 9834084 |doi=
*cite journal | author=McAlister MS, Davis B, Pfuhl M, Driscoll PC |title=NMR analysis of the N-terminal SRCR domain of human CD5: engineering of a glycoprotein for superior characteristics in NMR experiments. |journal=Protein Eng. |volume=11 |issue= 10 |pages= 847–53 |year= 1999 |pmid= 9862202 |doi=
*cite journal | author=Perez-Villar JJ, Whitney GS, Bowen MA, "et al." |title=CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 2903–12 |year= 1999 |pmid= 10082557 |doi=
*cite journal | author=Carmo AM, Castro MA, Arosa FA |title=CD2 and CD3 associate independently with CD5 and differentially regulate signaling through CD5 in Jurkat T cells. |journal=J. Immunol. |volume=163 |issue= 8 |pages= 4238–45 |year= 1999 |pmid= 10510361 |doi=
*cite journal | author=Vilà JM, Calvo J, Places L, "et al." |title=Role of two conserved cytoplasmic threonine residues (T410 and T412) in CD5 signaling. |journal=J. Immunol. |volume=166 |issue= 1 |pages= 396–402 |year= 2001 |pmid= 11123317 |doi=
*cite journal | author=Vilà JM, Gimferrer I, Padilla O, "et al." |title=Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases. |journal=Eur. J. Immunol. |volume=31 |issue= 4 |pages= 1191–8 |year= 2001 |pmid= 11298344 |doi=
*cite journal | author=Kirchgessner H, Dietrich J, Scherer J, "et al." |title=The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. |journal=J. Exp. Med. |volume=193 |issue= 11 |pages= 1269–84 |year= 2001 |pmid= 11390434 |doi=
*cite journal | author=Gary-Gouy H, Harriague J, Dalloul A, "et al." |title=CD5-negative regulation of B cell receptor signaling pathways originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif. |journal=J. Immunol. |volume=168 |issue= 1 |pages= 232–9 |year= 2002 |pmid= 11751967 |doi=
External links
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