GYPB

Glycophorin B (MNS blood group), also known as GYPB, is a human gene.cite web | title = Entrez Gene: GYPB glycophorin B (MNS blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2994| accessdate = ] GYPB has also recently been designated CD235b (cluster of differentiation 235b).

PBB_Summary
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summary_text = Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.cite web | title = Entrez Gene: GYPB glycophorin B (MNS blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2994| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: multiple gene rearrangements and modulation of splice site usage result in extensive diversification. |journal=Hum. Mutat. |volume=6 |issue= 3 |pages= 199–209 |year= 1996 |pmid= 8535438 |doi= 10.1002/humu.1380060302
*cite journal | author=Blumenfeld OO, Huang CH |title=Molecular genetics of glycophorin MNS variants. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=4 |issue= 4 |pages= 357–65 |year= 1997 |pmid= 9269716 |doi=
*cite journal | author=Huang CH, Spruell P, Moulds JJ, Blumenfeld OO |title=Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype. |journal=Blood |volume=80 |issue= 1 |pages= 257–63 |year= 1992 |pmid= 1611092 |doi=
*cite journal | author=Rearden A, Phan H, Dubnicoff T, "et al." |title=Identification of the crossing-over point of a hybrid gene encoding human glycophorin variant Sta. Similarity to the crossing-over point in haptoglobin-related genes. |journal=J. Biol. Chem. |volume=265 |issue= 16 |pages= 9259–63 |year= 1990 |pmid= 1971625 |doi=
*cite journal | author=Huang CH, Blumenfeld OO |title=Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins. |journal=Blood |volume=77 |issue= 8 |pages= 1813–20 |year= 1991 |pmid= 2015404 |doi=
*cite journal | author=Huang CH, Blumenfeld OO |title=Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification. |journal=J. Biol. Chem. |volume=266 |issue= 11 |pages= 7248–55 |year= 1991 |pmid= 2016325 |doi=
*cite journal | author=Kudo S, Fukuda M |title=Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction. |journal=J. Biol. Chem. |volume=265 |issue= 2 |pages= 1102–10 |year= 1990 |pmid= 2295603 |doi=
*cite journal | author=Kudo S, Fukuda M |title=Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 12 |pages= 4619–23 |year= 1989 |pmid= 2734312 |doi=
*cite journal | author=Tate CG, Tanner MJ |title=Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta. |journal=Biochem. J. |volume=254 |issue= 3 |pages= 743–50 |year= 1988 |pmid= 3196288 |doi=
*cite journal | author=Siebert PD, Fukuda M |title=Molecular cloning of a human glycophorin B cDNA: nucleotide sequence and genomic relationship to glycophorin A. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 19 |pages= 6735–9 |year= 1987 |pmid= 3477806 |doi=
*cite journal | author=Blanchard D, Dahr W, Hummel M, "et al." |title=Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis. |journal=J. Biol. Chem. |volume=262 |issue= 12 |pages= 5808–11 |year= 1987 |pmid= 3571235 |doi=
*cite journal | author=Dahr W, Beyreuther K, Moulds J, Unger P |title=Hybrid glycophorins from human erythrocyte membranes. I. Isolation and complete structural analysis of the hybrid sialoglycoprotein from Dantu-positive red cells of the N.E. variety. |journal=Eur. J. Biochem. |volume=166 |issue= 1 |pages= 31–6 |year= 1987 |pmid= 3595615 |doi=
*cite journal | author=Onda M, Fukuda M |title=Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA. |journal=Gene |volume=159 |issue= 2 |pages= 225–30 |year= 1995 |pmid= 7622054 |doi=
*cite journal | author=Kudo S, Onda M, Fukuda M |title=Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals. |journal=J. Biochem. |volume=116 |issue= 1 |pages= 183–92 |year= 1995 |pmid= 7798177 |doi=
*cite journal | author=Rahuel C, Elouet JF, Cartron JP |title=Post-transcriptional regulation of the cell surface expression of glycophorins A, B, and E. |journal=J. Biol. Chem. |volume=269 |issue= 52 |pages= 32752–8 |year= 1995 |pmid= 7806496 |doi=
*cite journal | author=Huang CH, Reid ME, Blumenfeld OO |title=Remodeling of the transmembrane segment in human glycophorin by aberrant RNA splicing. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10804–12 |year= 1994 |pmid= 8144668 |doi=
*cite journal | author=Huang CH, Lomas C, Daniels G, Blumenfeld OO |title=Glycophorin He(Sta) of the human red blood cell membrane is encoded by a complex hybrid gene resulting from two recombinational events. |journal=Blood |volume=83 |issue= 11 |pages= 3369–76 |year= 1994 |pmid= 8193374 |doi=
*cite journal | author=Huang CH, Reid ME, Blumenfeld OO |title=Exon skipping caused by DNA recombination that introduces a defective donor splice site into the human glycophorin A gene. |journal=J. Biol. Chem. |volume=268 |issue= 7 |pages= 4945–52 |year= 1993 |pmid= 8444872 |doi=
*cite journal | author=Cherif-Zahar B, Raynal V, Gane P, "et al." |title=Candidate gene acting as a suppressor of the RH locus in most cases of Rh-deficiency. |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 168–73 |year= 1996 |pmid= 8563755 |doi= 10.1038/ng0296-168

External links

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